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- W2181772022 abstract "Greenseasons Biotech Company, Ltd. (GBC), a private contract research organization (CRO), founded recently, along with a semi-governmental-run CRO on this island handles most of commercial biosafety testing business for 'healthy-food development' regulatory purpose in Taiwan. The company has operated with limited resources and thus, utilized the 'Reduction principle of the 3Rs' as one way to not only enhance animal welfare, but also to conserve these limited resources without compromising the quality of the scientific data. One of the efforts has been to reducing animal number in rodents for testing. The basic premise is to share the control group between studies having similar nature of test articles and similar procedures, such as route of administration and length of study. Another effort is applying in pyrogenic/ fever study with New Zealand white rabbits such that the rabbits were repeatedly to use for 3 to 5 testing with 3 weeks apart between tests as long as the welfare of the animals is not compromised, as evaluated by the animal displaying no adverse reaction or abnormality. The effort approved by our Institutional Animal Care and Use Committee (IACUC) was supported by the team of Experimental Animal Ethics Committee appointed by the gubernatorial Council of Agriculture upon inspection. We welcome comments from abroad and international society on this issue and we would appreciate it for any input on this endeavored effort that we could try and perform for more." @default.
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- W2181772022 date "2008-01-01" @default.
- W2181772022 modified "2023-09-24" @default.
- W2181772022 title "Practical consideration of 3Rs' reduction principle in a private sector CRO on Taiwan" @default.
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