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• W2181799559 abstract "From the past few decades nasal route become an important area of interest for researcher due to some important characteristics like highly porous endothelial membrane, large surface area, vascularized epithelium, high perfusion rate, avoidance of hepatic first pass metabolism. Beside these properties, the nasal route also has some major limitations like administration of drug from its dosage form and mucociliary clearance retard the proper absorption of drug; the effect of such limitations can be overcome by using an approach namely in-situ mucoadhesive gel. Basically in-situ means the formulation is found sol type in nature (storage conditions) but when administered to the nasal cavity, the transitions of phase occurs and get converted to the gel form; so this property facilitate the administration of dosage form. The gelation occurs by the effect of temperature, change in pH etc. In another side mucoadhesive nature of gel retain the dosage form against mucociliary clearance; so enhance the absorption as well as bioavailability of dosage form. In the present study we are discussing about various basic properties, advantages, disadvantages, anatomy and physiology of nasal route. In this study, we also discussing about various kinds of dosage form with special emphasizing on in-situ mucoadhesive dosage form for nasal drug delivery. The present study also covers some research and patents on nasal drug delivery." @default.
• W2181799559 created "2016-06-24" @default.
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• W2181799559 date "2014-01-01" @default.
• W2181799559 modified "2023-09-24" @default.
• W2181799559 title "Nasal Drug Delivery with Special Focus on In-situ Mucoadhesive Gel: A Review" @default.
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• W2181799559 hasPublicationYear "2014" @default.
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