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- W2181820804 abstract "SYNOPSISBecause theyare cumbersome, tests todetermine thequantitative susceptibility of organisms toantimicrobial drugs arenotperformed routinely inmany diagnostic laboratories. Thispaperdescribes a simple methodofincorporating theantimicrobial druginagar.Itisan adaptation oftheRolinson andRussell technique whichallows thedetermination ofminimum inhibitory concentrations (MIC)ofantimicrobial drugs fora large numberoforganisms. Results arecomparable withthoseobtained whenthestandard agardilution methodisused. Strains of aerobic Gram-negative bacilli weretested bybothmethods using ampicillin (86strains), cephaloridine(72strains), trimethoprim (72strains), andgentamicin (72strains). Ofthe302tests thus performed, a difference inMIC ofmore thanone double dilution was noted inonly 11 tests. With one strain ofPseudomonas aeruginosa, however, itwas notpossible todetect ampicillin resistance bythemethoddescribed inthis paper. Itiscommonpractice toreport thesusceptibility of anorganism isolated fromapatient andconsidered tobeofclinical significance aseither 'sensitive' or 'resistant' to a particular antimicrobial drug. Laboratory methods forassessing thesusceptibility ofanorganism tosuchdrugs vary. Broadly, they fall into twogroups-disc diffusion tests anddilution tests. Because theyaresimple toperform, disc diffusion tests areusedroutinely inmanydiagnostic laboratories. Several studies havebeenperformed tocompare results ofantimicrobial sensitivity tests obtained by different laboratories onstrains oforganisms sent either assimulated clinical specimens oraspure cultures (Institute ofMedical Laboratory Technology, 1960; Association ofClinical Pathologists, 1965; College ofPathologists ofAustralia, 1968; Castle andElstub, 1971). Thesestudies haveshown awiderangeofdiscrepant results andthis hasgiven causeforconcern. Inrecent yearsattempts havebeenmadeto standardize disc diffusion tests andtointerpret zone diameters intermsofminimum inhibitory concentrations (MIC)oftheantimicrobial substance (Bauer etal,1966; Ericsson andSherris, 1971). Suchmethods require rigid standardization and,whenperformed asrecommended, aretimeconsuming andlaborious." @default.
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- W2181820804 date "1975-01-01" @default.
- W2181820804 modified "2023-09-27" @default.
- W2181820804 title "Determination ofantimicrobial MICbypaper diffusion method" @default.
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- W2181820804 hasPublicationYear "1975" @default.
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