FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2181844174> ?p ?o ?g. }

• W2181844174 abstract "Background & Aims: Liver-specific inactivation of carcinoembryonic antigen‐related cell adhesion molecule 1 causes hyperinsulinemia and insulin resistance, which result from impaired insulin clearance, in liverspecific S503A carcinoembryonic antigen‐related cell adhesion molecule 1 mutant mice (L-SACC1). These mice also develop steatosis. Because hepatic fat accumulation precedes hepatitis, lipid peroxidation, and apoptosis in the pathogenesis of nonalcoholic steatohepatitis (NASH), we investigated whether a high-fat diet, by causing inflammation, is sufficient to induce hepatitis and other features of NASH in L-SACC1 mice. Methods: L-SACC1 and wild-type mice were placed on a high-fat diet for 3 months, then several biochemical and histologic analyses were performed to investigate the NASH phenotype. Results: A high-fat diet caused hepatic macrosteatosis and hepatitis, characterized by increased hepatic tumor necrosis factor levels and activation of the NF-B pathway in L-SACC1 but not in wild-type mice. The high-fat diet also induced necrosis and apoptosis in the livers of the L-SACC1 mice. Insulin resistance in L-SACC1 fed a high-fat diet increased the hepatic procollagen protein level, suggesting a role in the development of fibrosis. Conclusions: A high-fat diet induces key features of human NASH in insulinresistant L-SACC1 mice, validating this model as a tool to study the molecular mechanisms of NASH." @default.
• W2181844174 created "2016-06-24" @default.
• W2181844174 creator A5002703391 @default.
• W2181844174 creator A5010457708 @default.
• W2181844174 creator A5021928876 @default.
• W2181844174 creator A5033007531 @default.
• W2181844174 creator A5039158373 @default.
• W2181844174 creator A5081025063 @default.
• W2181844174 creator A5088611335 @default.
• W2181844174 creator A5082519030 @default.
• W2181844174 date "2008-01-01" @default.
• W2181844174 modified "2023-09-27" @default.
• W2181844174 title "BASIC—LIVER, PANCREAS, AND BILIARY TRACT Development of Nonalcoholic Steatohepatitis in Insulin-Resistant Liver-Specific S503A Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Mutant Mice" @default.
• W2181844174 cites W1506034405 @default.
• W2181844174 cites W1523158326 @default.
• W2181844174 cites W1533883710 @default.
• W2181844174 cites W1534360145 @default.
• W2181844174 cites W1784667903 @default.
• W2181844174 cites W1970455281 @default.
• W2181844174 cites W1974863952 @default.
• W2181844174 cites W1979605665 @default.
• W2181844174 cites W1989535259 @default.
• W2181844174 cites W1991401793 @default.
• W2181844174 cites W1992565781 @default.
• W2181844174 cites W1993702135 @default.
• W2181844174 cites W1996559225 @default.
• W2181844174 cites W2014174246 @default.
• W2181844174 cites W2019973807 @default.
• W2181844174 cites W2022807068 @default.
• W2181844174 cites W2026483481 @default.
• W2181844174 cites W2027391841 @default.
• W2181844174 cites W2032479841 @default.
• W2181844174 cites W2045081851 @default.
• W2181844174 cites W2045510035 @default.
• W2181844174 cites W2047257800 @default.
• W2181844174 cites W2047309793 @default.
• W2181844174 cites W2054208989 @default.
• W2181844174 cites W2070053386 @default.
• W2181844174 cites W2071988426 @default.
• W2181844174 cites W2076858432 @default.
• W2181844174 cites W2077807148 @default.
• W2181844174 cites W2083050494 @default.
• W2181844174 cites W2088676276 @default.
• W2181844174 cites W2090699947 @default.
• W2181844174 cites W2092189965 @default.
• W2181844174 cites W2096458076 @default.
• W2181844174 cites W2106071911 @default.
• W2181844174 cites W2128569391 @default.
• W2181844174 cites W2128891409 @default.
• W2181844174 cites W2130280258 @default.
• W2181844174 cites W2132924550 @default.
• W2181844174 cites W2133560683 @default.
• W2181844174 cites W2134466661 @default.
• W2181844174 cites W2136856218 @default.
• W2181844174 cites W2138526449 @default.
• W2181844174 cites W2144178804 @default.
• W2181844174 cites W2146544786 @default.
• W2181844174 cites W2147203117 @default.
• W2181844174 cites W2157064056 @default.
• W2181844174 cites W2162403539 @default.
• W2181844174 cites W2163505977 @default.
• W2181844174 cites W2167743390 @default.
• W2181844174 cites W2406176114 @default.
• W2181844174 cites W2513800141 @default.
• W2181844174 cites W44255872 @default.
• W2181844174 hasPublicationYear "2008" @default.
• W2181844174 type Work @default.
• W2181844174 sameAs 2181844174 @default.
• W2181844174 citedByCount "0" @default.
• W2181844174 crossrefType "journal-article" @default.
• W2181844174 hasAuthorship W2181844174A5002703391 @default.
• W2181844174 hasAuthorship W2181844174A5010457708 @default.
• W2181844174 hasAuthorship W2181844174A5021928876 @default.
• W2181844174 hasAuthorship W2181844174A5033007531 @default.
• W2181844174 hasAuthorship W2181844174A5039158373 @default.
• W2181844174 hasAuthorship W2181844174A5081025063 @default.
• W2181844174 hasAuthorship W2181844174A5082519030 @default.
• W2181844174 hasAuthorship W2181844174A5088611335 @default.
• W2181844174 hasConcept C121608353 @default.
• W2181844174 hasConcept C126322002 @default.
• W2181844174 hasConcept C134018914 @default.
• W2181844174 hasConcept C2776175330 @default.
• W2181844174 hasConcept C2777387746 @default.
• W2181844174 hasConcept C2777391703 @default.
• W2181844174 hasConcept C2778772119 @default.
• W2181844174 hasConcept C2779134260 @default.
• W2181844174 hasConcept C2779306644 @default.
• W2181844174 hasConcept C2779478299 @default.
• W2181844174 hasConcept C2780559512 @default.
• W2181844174 hasConcept C71924100 @default.
• W2181844174 hasConcept C86803240 @default.
• W2181844174 hasConceptScore W2181844174C121608353 @default.
• W2181844174 hasConceptScore W2181844174C126322002 @default.
• W2181844174 hasConceptScore W2181844174C134018914 @default.
• W2181844174 hasConceptScore W2181844174C2776175330 @default.
• W2181844174 hasConceptScore W2181844174C2777387746 @default.
• W2181844174 hasConceptScore W2181844174C2777391703 @default.
• W2181844174 hasConceptScore W2181844174C2778772119 @default.
• W2181844174 hasConceptScore W2181844174C2779134260 @default.
• W2181844174 hasConceptScore W2181844174C2779306644 @default.

• next