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- W2181922014 abstract "An inhibitor ofmyeloperoxidase hasbeen identified inthesynovial fluids andserafrom patients withrheumatoid arthritis andsera fromnormalsubjects. Initially, thesefluids werefoundtoinhibit stimulus induced degranulation ofpolymorphonuclear leucocytes independently of thestimulating agent. Subsequently, thefluids wereshowntoinhibit thereleased enzymerather thanthedegranulation response ofpolymorphonuclear leucocytes. Bothrheumatoid andnormalserum samples contained highconcentrations ofthe inhibitor buttheconcentrations werelower in rheumatoid synovial fluids. Theinhibitory activity seemed tobespecific forperoxidase asthefluids didnotinhibit 3-glucuronidase activity. Aprotein ofrelative molecular mass (Mr)150kdwaspurified fromsynovial fluid byaffinity chromatography onmyeloperoxidase-Sepharose. Itisconcluded thatserum andsynovial fluid contain a novelmyeloperoxidase inhibitor, whichactsbybinding tomyeloperoxidase andthereby prevents myeloperoxidase releasing oxidative products inserum." @default.
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- W2181922014 date "1991-01-01" @default.
- W2181922014 modified "2023-09-26" @default.
- W2181922014 title "Inhibition ofmyeloperoxidase bysynovial fluid and serum" @default.
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