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- W2181930845 abstract "Cholesterol-feeding of hypothyroid Long-Evans rats results in a marked hypercholesterolemia and hepatic secre- tion of cholesteryl ester and apoE-rich VLDL and LDL which accumulate in the serum compartment (J Lipid Res. 198 1 22: 971-989). The present study segregates the effects of hypo- thyroidism from the combined effects reported above. Hy- pothyroidism alone does not result in the secretion of choles- teryl ester-rich lipoproteins by the liver which, in contrast, contains depressed quantities (30%) of triglyceride-rich (7 1 % of lipid mass) VLDL and low levels of LDL which is also tri- glyceride-rich when compared to the nascent lipoproteins of euthyroid rat livers. The nascent lipoproteins from the hepatic Golgi cisternae and secretory vesicles of hypothyroid rats all had pre-@ or slow pre-P migration on agarose gel electropho- resis and were very dissimilar in lipid and apoprotein com- position from the b-migrating LDL that accumulates in the sera of these animals and contains 13.8% triglyceride, 51.3% cholesteryl ester, and has an apoB/apoE ratio of 32.7.1 We conclude that the serum LDL in hypothryoid rats, which con- tains only apoBloo, is not secreted directly by the liver but represents a normal catabolite of triglyceride-rich VLDL that may accumulate due to reduced receptor-mediated clearance rather than an overproduction of its immediate precursor, hepatic VLDL.-Dolphin, P. J., and S. J. Forsyth. Nascent hepatic lipoproteins in hypothyroid rats. J. Lipid Res. 1983. 24: 541-551." @default.
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- W2181930845 date "1983-05-01" @default.
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- W2181930845 title "Nascent hepatic lipoproteins in hypothyroid rats." @default.
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- W2181930845 doi "https://doi.org/10.1016/s0022-2275(20)37959-1" @default.
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