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- W2181933022 abstract "Background: Multiple sclerosis (MS) is the most common disabling neurological disease in young adults characterized by recurrent relapses and/or progression. Multiple sclerosis was the first neurological disease in which transcranial magnetic stimulation (TMS) was used. Objective: The aim of this study is to assess the relationship between the level of cerebral excitability and clinical phase of MS (the relapsing and remitting phases of MS). Methods: Forty patients affected by relapsing-remitting (RR) MS were examined using single TMS in order to assess excitability changes in the hand motor cortex occurring during relapse and/or remission of the disease. The analyzed parameters were: motor threshold, amplitude of motor evoked potential (MEP), silent period (SP), and central motor conduction time (CMCT). Results: The analysis of variance exhibited a strong correlation (P<0.001) between the clinical phase and the type of excitability changes: ‘relapsing’ patients showed increased threshold and reduced SP duration. ‘By contrast, ‘remitting’ patients showed a significant SP prolongation with normal motor thresholds. Conclusion: TMS is a highly sensitive non invasive technique recommended to evaluate conduction abnormalities and cortical excitability changes and in monitoring the course of the disease in relapsing-remitting MS. [Egypt J Neurol Psychiat Neurosurg. 2010; 47(4): 535-540]" @default.
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- W2181933022 date "2010-01-01" @default.
- W2181933022 modified "2023-09-24" @default.
- W2181933022 title "Brain Excitability Changes in the Relapsing and Remitting Phases of Multiple Sclerosis: A Study with Transcranial Magnetic Stimulation" @default.
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