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- W2181946838 abstract "Background: Recently man has started depending on natural resources even for his healthcare. Problems with drug resistant microorganisms, side effects of the modern medicine and the increasing number of emerging diseases for which no cure is available in modern medicine has renewed the interest in plants as a significant source of therapeutics. Primary Study Objective: Liver is a versatile organ that regulates the internal environment of the body and hence becomes prone to toxicity. Despite the tremendous strides in modern medicine there is still a need for a drug that stimulates liver function. Hence the present study focuses on the study of the hepatoprotective potentials of Ocimum sanctum Linn. in lead induced toxicity. Methods and Design: Aqueous extract of O. sanctum was prepared as per protocol. Wistar strains of Albino rats were used as the experimental models. Animals were grouped into six comprising of six rats each. Hepatotoxicity was induced using lead. The selected plant drug was administered to the animals orally for a period of 21 days. The Hepatic serum markers AST, ALT, ALP, GGT, Serum Protein, Serum Bilirubin and Tissue Glycogen were analyzed. The antioxidant status of the animals was also assessed in the animals by measuring the activity of GSH and SOD. The extent of lipid per oxidation (LPO) was also measured. Results: The results obtained depicted the protective nature of the selected drug source. The induction of liver injury with lead resulted in significant raise in the serum marker enzyme level along with an increase in the serum bilirubin content. The inactivation of the liver was evident from the lowered levels of serum protein and tissue glycogen levels. The antioxidant status was very low thus causing an accumulation in lipid peroxides in the hepatic tissues. All the parameters studied were restored to near normal when treated with the aqueous extract of O. sanctum. Values, p<0.05 were considered statistically significant. Conclusion: The present study clearly depicts the hepatoprotective nature of O.sanctum in lead induced toxicity. The protective activity may be attributed to the antioxidant activity of the plant." @default.
- W2181946838 created "2016-06-24" @default.
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- W2181946838 date "2011-01-01" @default.
- W2181946838 modified "2023-09-27" @default.
- W2181946838 title "HEPATOPROTECTIVE ACTIVITY OF OCIMUM SANCTUM LINN. AGAINST LEAD INDUCED TOXICITY IN ALBINO RATS" @default.
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