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• W2181979145 abstract "The Na + pump, Na + -K + -ATPase, along with the Na + channel is essential for the removal of alveolar solute and fluid perinatally. Because Na + -pump mRNA and activity increase before birth and maternal glucocorticoids (GCs) influence Na + -K + -ATPase mRNA expression in fetal rat lung, we hypothesized that GCs increased Na + -K + -ATPase gene expression in a fetal lung epithelial cell line. After 24 h of exposure, dexamethasone increased the steady-state levels of Na + -K + -ATPase α 1 and β 1 mRNA in a fetal rat lung epithelial cell line in a dose-dependent fashion (10 −7 to 10 −5 M). The maximal increase in mRNA levels was 3.8-fold for α 1 and 2.8-fold for β 1 . The increase in mRNA was detected as early as 6 h for the β 1 -subunit and 18 h for the α 1 -subunit, and both peaked at 24 h. This gene upregulation was not due to increased mRNA stability based on mRNA half-life determination after actinomycin D inhibition. Transfection experiments with α 1 and β 1 promoter-reporter constructs demonstrated 3.2 ± 0.5- and 2.6 ± 0.4-fold increases, respectively, in promoter activity, consistent with transcriptional activation of the promoter-reporter construct. These findings, increased promoter activity with no change in stability, indicate that GCs increased Na + -K + -ATPase transcription in a fetal lung epithelial cell line." @default.
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• W2181979145 date "1999-07-01" @default.
• W2181979145 modified "2023-10-16" @default.
• W2181979145 title "Na⁺-K⁺-ATPase gene regulation by glucocorticoids in a fetal lung epithelial cell line" @default.
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• W2181979145 doi "https://doi.org/10.1152/ajplung.1999.277.1.l197" @default.
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