FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182006876> ?p ?o ?g. }

• W2182006876 abstract "To understand biology at a system level, I presented novel machine learning algorithms to reveal the underlying mechanisms of how genes and their products function in different biological levels in this thesis. Specifically, at sequence level, based on Kernel Support Vector Machines (SVMs), I proposed learned random-walk kernel and learned empirical-map kernel to identify protein remote homology solely based on sequence data, and I proposed a discriminative motif discovery algorithm to identify sequence motifs that characterize protein sequences’ remote homology membership. The proposed approaches significantly outperform previous methods, especially on some challenging protein families. At expression and protein level, using hierarchical Bayesian graphical models, I developed the first high-throughput computational predictive model to filter sequence-based predictions of microRNA targets by incorporating the proteomic data of putative microRNA target genes, and I proposed another probabilistic model to explore the underlying mechanisms of microRNA regulation by combining the expression profile data of messenger RNAs and microRNAs. At cellular level, I further investigated how yeast genes manifest their functions in cell morphology by performing gene function prediction from the morphology data of yeast temperature-sensitive alleles. The developed prediction models enable biologists to choose some interesting yeast essential genes and study their predicted novel functions." @default.
• W2182006876 created "2016-06-24" @default.
• W2182006876 creator A5000236616 @default.
• W2182006876 date "2010-01-01" @default.
• W2182006876 modified "2023-09-27" @default.
• W2182006876 title "Machine learning approaches to biological sequence and phenotype data analysis" @default.
• W2182006876 cites W14071851 @default.
• W2182006876 cites W144423133 @default.
• W2182006876 cites W1480376833 @default.
• W2182006876 cites W1506806321 @default.
• W2182006876 cites W1511160855 @default.
• W2182006876 cites W1512098439 @default.
• W2182006876 cites W1516111018 @default.
• W2182006876 cites W1560724230 @default.
• W2182006876 cites W1582076997 @default.
• W2182006876 cites W1596877211 @default.
• W2182006876 cites W1598700272 @default.
• W2182006876 cites W1953939973 @default.
• W2182006876 cites W1963952972 @default.
• W2182006876 cites W1966241066 @default.
• W2182006876 cites W1967073510 @default.
• W2182006876 cites W1974220691 @default.
• W2182006876 cites W1978270504 @default.
• W2182006876 cites W1978337436 @default.
• W2182006876 cites W1988163167 @default.
• W2182006876 cites W1990868443 @default.
• W2182006876 cites W1992402718 @default.
• W2182006876 cites W1995918845 @default.
• W2182006876 cites W2013570924 @default.
• W2182006876 cites W2014946489 @default.
• W2182006876 cites W2017199818 @default.
• W2182006876 cites W2017270642 @default.
• W2182006876 cites W2042004955 @default.
• W2182006876 cites W2045234988 @default.
• W2182006876 cites W2045656233 @default.
• W2182006876 cites W2047429137 @default.
• W2182006876 cites W2048599311 @default.
• W2182006876 cites W2049633694 @default.
• W2182006876 cites W2050869737 @default.
• W2182006876 cites W2065566217 @default.
• W2182006876 cites W2069429561 @default.
• W2182006876 cites W2083381199 @default.
• W2182006876 cites W2084407186 @default.
• W2182006876 cites W2085277871 @default.
• W2182006876 cites W2085316301 @default.
• W2182006876 cites W2089142809 @default.
• W2182006876 cites W2096373458 @default.
• W2182006876 cites W2102122585 @default.
• W2182006876 cites W2107725114 @default.
• W2182006876 cites W2108447811 @default.
• W2182006876 cites W2113390076 @default.
• W2182006876 cites W2113592823 @default.
• W2182006876 cites W2118670840 @default.
• W2182006876 cites W2120456037 @default.
• W2182006876 cites W2122837498 @default.
• W2182006876 cites W2127464112 @default.
• W2182006876 cites W2130362663 @default.
• W2182006876 cites W2133968430 @default.
• W2182006876 cites W2135624716 @default.
• W2182006876 cites W2136490963 @default.
• W2182006876 cites W2138312771 @default.
• W2182006876 cites W2142387771 @default.
• W2182006876 cites W2142437744 @default.
• W2182006876 cites W2143426320 @default.
• W2182006876 cites W2143797877 @default.
• W2182006876 cites W2145295623 @default.
• W2182006876 cites W2149386535 @default.
• W2182006876 cites W2155063211 @default.
• W2182006876 cites W2156455118 @default.
• W2182006876 cites W2156909104 @default.
• W2182006876 cites W2158266063 @default.
• W2182006876 cites W2158714788 @default.
• W2182006876 cites W2159460045 @default.
• W2182006876 cites W2163199119 @default.
• W2182006876 cites W2169600668 @default.
• W2182006876 cites W2170694711 @default.
• W2182006876 cites W2171095014 @default.
• W2182006876 cites W2283504545 @default.
• W2182006876 cites W2292609460 @default.
• W2182006876 cites W2296319761 @default.
• W2182006876 cites W2911964244 @default.
• W2182006876 cites W579662085 @default.
• W2182006876 hasPublicationYear "2010" @default.
• W2182006876 type Work @default.
• W2182006876 sameAs 2182006876 @default.
• W2182006876 citedByCount "0" @default.
• W2182006876 crossrefType "dissertation" @default.
• W2182006876 hasAuthorship W2182006876A5000236616 @default.
• W2182006876 hasConcept C104317684 @default.
• W2182006876 hasConcept C105565629 @default.
• W2182006876 hasConcept C117745874 @default.
• W2182006876 hasConcept C119857082 @default.
• W2182006876 hasConcept C122280245 @default.
• W2182006876 hasConcept C12267149 @default.
• W2182006876 hasConcept C141231307 @default.
• W2182006876 hasConcept C154945302 @default.
• W2182006876 hasConcept C41008148 @default.
• W2182006876 hasConcept C54355233 @default.
• W2182006876 hasConcept C70721500 @default.
• W2182006876 hasConcept C86803240 @default.

• next