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- W2182016687 abstract "2 ABSTRACT Hyperhomocysteinemia, when considered as a causal factor of vascular diseases, has been subject of much discussion. Case-control, retrospective and prospective studies have identified a relationship between high plasma concentrations of homocysteine and vascular disease. The aim of the present review was to better understand the interrelation between plasma concentra- tions of homocysteine and vascular diseases, as well as the involvement of classical risk factors for the disease: genetic factors, such as mutations in the genes that codify the enzymes involved in the metabolism of homocysteine, and nutritional factors, such as complex B vitamin deficien- cy. The publications of the main databases in health were consulted for the period 1962 to 2009. The mechanism by which hyperhomocysteinemia acts as a risk factor for vascular diseases still has not been fully clarified, but involvement of endothelial dysfunction and lipid peroxidation is suggested. The treatment of hyperhomocysteinemia is based on food supplements and medica- tion, with folic acid and vitamins B6 and B12. Arq Bras Endocrinol Metab. 2009;53(5):540-9." @default.
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- W2182016687 date "2009-01-01" @default.
- W2182016687 modified "2023-09-27" @default.
- W2182016687 title "Hiper-homocisteinemia e risco cardiometabólico Hyperhomocysteinemia and cardiometabolic risk" @default.
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