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- W2182021958 abstract "Toscana Virus (TOSV) is a Phlebovirus responsible for central nervous system (CNS) injury in humans. The TOSV non-structural protein (NSs), which interacting with RIG-I leads to its degradation, was analysed in the C terminus fragment in order to identify its functional domains. To this aim, two C-terminal truncated NSs proteins, Δ1C-NSs (aa 1-284) and Δ2C-NSs (aa 1-287) were tested. Only Δ1C-NSs did not present any inhibitory effect on RIG-I and it showed a greater stability than the whole NSs protein. Moreover, the deletion of the TLQ aa sequence interposed between the two ΔC constructs caused a greater accumulation of the protein with a weak inhibitory effect on RIG-I, indicating some involvement of these amino acids in the NSs activity. Nevertheless, all the truncated proteins were still able to interact with RIG-I, suggesting that the domains responsible for RIG-I signaling and RIG-I interaction are mapped on different regions of the protein." @default.
- W2182021958 created "2016-06-24" @default.
- W2182021958 creator A5018317652 @default.
- W2182021958 creator A5029614536 @default.
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- W2182021958 date "2015-12-01" @default.
- W2182021958 modified "2023-09-28" @default.
- W2182021958 title "Truncation of the C-terminal region of Toscana Virus NSs protein is critical for interferon-β antagonism and protein stability" @default.
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- W2182021958 doi "https://doi.org/10.1016/j.virol.2015.09.021" @default.
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