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- W2182036499 abstract "ENGLISH/ANGLAIS] Affiliations: 1 Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NIGERIA 2 Department of Anatomy, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NIGERIA * Email Address for Correspondence/ Adresse de courriel pour la correspondance: jy_ayodeji@yahoo.co m Accepted/Accept: February, 2012 Full Citation: Ajayi AF, Jegede AI. Reproductive Profile of Male Wistar Rats Treated with Graded Doses of Aqueous Extract of Titonia diversifolia Leaf. World Journal of Life Sciences and Medical Research 2012;2(2):48-53. The effect of an aqueous extract of Titonia diversifolia (AETD) was investigated on morphometric of testis, hormonal assay and semen analysis of caudal epididymes of 24 male Wistar rats. They were divided into four groups of six rats each, Group A served as the control and was administered distilled water while groups B, C and D were treated with 50mg/kg,100mg/kg and 200mg/kg body weight of aqueous extract of Titonia diversifolia respectively for 28 days. The result of the study showed that aqueous extract of Titonia diversifolia affect the morphometric of testis showing a significant (p < 0.05) decrease in width, length and weight at 100mg/kg AETD, the right epididymidis was also significantly reduced in weight at 100mg/kg of AETD. Plasma testosterone significantly increased at 50mg/kg of AETD.The highest sperm count, motility, viability was also recorded at a dose of 50mg/kg. Phytochemical screening of the extract showed the presence of tannins and saponins. Aqueous extract of Titonia diversifolia at a dose of 100mg/kg and 200mg/kg possesses the potential to reduce sperm count, motility, morphology, and viability. While a dose of 50mg/kg increased the sperm count, motility and viability, and the plasma testosterone was also increased at 50mg/kg of AETD.Therefore, 50mg/kg of the extract will increase the testosterone level, thereby improving spermatogenesis and other reproductive profile." @default.
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- W2182036499 title "Reproductive Profile of Male Wistar Rats Treated with Graded Doses of Aqueous Extract of Titonia diversifolia Leaf" @default.
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