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• W2182073955 abstract "The pathways and some critical enzymes involved in lipogenesis in adipose tissue from 82 patients have been studied. Of the glucose-14C metabolized to lipid by isolated adipose cells, approximately 0.6% was recovered in fatty acids and the rest in glyceride-glycerol. Palmitate-lJ4C was readily incorporated into neutral lipid. Homogenates of human adipose tissue contained an active a-glycerophosphate dehydrogenase which was approximately twice as active as malate dehydrogenase. Mitochondria of human adipose tissue contained an NAD-independent a- glycerophosphate dehydrogenase; the reaction product, di- hydroxyacetone phosphate, was recovered extramitochon- drially. Homogenates of human adipose tissue also contained an active fatty acyl CoA synthetase which required ATP, CoA, and Mgff for maximal activity. The activity of acyl CoA synthetase varied greatly in a group of 40 patients. By contrast, the range of activity of malate dehydrogenase assayed in the same group of patients was much smaller. When palmitate or palmitoyl CoA was used as substrate, no difference was found in the rate of incorporation of a-glycerol- 1,3-14C phosphate into neutral lipid. If time was allowed for activation of palmitate, the incorporation of a-glycerol-1 ,3-14C phosphate into lipid was 3.5 times greater than for unactivated palmitate. Palmitate (200 p~) stimulated lipogenesis in homogenates of human adipose tissue and then caused a severe inhibition at 700 PM. Arachidate over the same concentration range did not depress lipogenesis below initial values. glycerol from glucose. Jansen, Hutchison, and Zanetti (2) found that in the mouse 90% of the glucoseJ*C converted into fat by epididymal fat pads is recovered in fatty acids and only 10% in glyceride-glycerol, whereas Goodridge and Ball (3) found that in the pigeon only about 7% of the glucose is metabolized to long-chain fatty acids by adipose tissue. The situation in man is not entirely clear. Reports have variously indicated that human adipose tissue, in vitro, can convert 16% of metabolized glucose to fatty acids and 84% to glyceride- glycerol (4) ; that the synthesis of fatty acids from glucose is quite variable and, in some cases, undetectable (5) ; and that human adipose tissue is probably an unimpor- tant site of synthesis of fatty acids since it lacks citrate cleavage enzyme (6). Although part of this variability may be due to nothing more than the different nutritional states of the subjects under study, further investigation seemed indicated. The present studies were designed to examine in more detail the paths of lipogenesis in human adipose tissue and provide information on some of the important enzymatic steps involved." @default.
• W2182073955 created "2016-06-24" @default.
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• W2182073955 date "1968-01-01" @default.
• W2182073955 modified "2023-10-18" @default.
• W2182073955 title "Lipogenesis in human adipose tissue" @default.
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• W2182073955 doi "https://doi.org/10.1016/s0022-2275(20)43138-4" @default.
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