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- W2182094851 abstract "SUMMARY Serologic markers fordelta agent wereevaluated in39patients withacutehepatitis B andclinical relapse within 30daysfromtheinitial episode. Eighteen ofthe39patients (46%)had evidence ofacutedelta infection. Deltaantigenaemia preceded theappearanceofantibodies in sevenofthese 18patients; delta antigenaemia occurred during theinitial episode ofillness and theappearanceoftheantibody coincided withtherelapse. Eight ofthese patients developed severerelapse withfulminant coursewhichresulted intwodeaths. Thisstudy reveals thatdelta infection isone oftheimportant causesofsevererelapse incasesofacuteB viral hepatitis. Infectivity studies inchimpanzees haveshownthat simultaneous infection with delta agent andhepatitis B virus (HBV)canresult inapeculiar sequential expression associated withbimodal disease. Multipleepisodes ofserumaminotransferase (ALT)rises havebeenreported asafeature ofacutehepatitis amongdrugaddicts using parenteral route.23 The prevalence rateofdelta infection hasbeenreported tobehighinthesamegroup.47 Hence, thetwo bouts ofALTrises occurring afewweeksapart in these patients probably represents abiphasic hepatitis fromco-infections ofHBV anddelta agent. In order toinvestigate this possibility andtoestablish thesequential serologic eventsinpatients with concurrent HBV anddelta infection, serafrom39 patients withbiphasic acute hepatitis wereexamined forall themarkers ofdelta. A significant numberof thesepatients withbiphasic orrelapse ofacute hepatitis showed evidence ofacute delta infection. Methods PATIENTS Serial serumsamples wereavailable fromtheonset ofinitial illness in39patients witha clinical diagnosis ofrelapse ofacute Bhepatitis. Therelapse occurred within four weeksoftheinitial illness inall these patients. Themajority ofthese patients (80%) werefoundtobeintravenous drugaddicts." @default.
- W2182094851 created "2016-06-24" @default.
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- W2182094851 date "1986-01-01" @default.
- W2182094851 modified "2023-09-24" @default.
- W2182094851 title "Relapse ofacuteBviral hepatitis - role ofdelta agent" @default.
- W2182094851 cites W1979980022 @default.
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- W2182094851 hasPublicationYear "1986" @default.
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