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- W2182105217 abstract "Rheumatoid arthritis (RA) is a chronic inflammatory systemic disorder with an autoimmune pathogenesis. Rheumatoid arthritis associated auto-antibodies are helpful serological tools in stating the definite diagnosis. Therefore, we aimed in our study to evaluate the diagnostic performances of anti-cyclic citrullinated peptides antibody (anti-CCP) assay and Rheumatoid Factor (RF IgM) by enzyme linked immunosorbent assay (ELISA) in patients with RA in Syria. Anti-CCP and RF assays were performed in 70 RA patients, and healthy control patients. The cut-off values recommended by the respective manufacturers were used to determine the sensitivity and specificity. Our study shows that Sensitivity of anti-CCP was similar to RF-IgM (65.7%) with better specificity (100% vs 94.4%) The combination of rheumatoid factor (RF) and antibodies against cyclic citrullinated provide better specificity to RF-IgM. In conclusion, Anti-CCP assay could be a useful serological test for the diagnosis of Syrian patients with RA, because anti-CCP revealed higher diagnostic specificity than RF, but combination of these two markers can increase RF-IgM specificity" @default.
- W2182105217 created "2016-06-24" @default.
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- W2182105217 date "2013-01-01" @default.
- W2182105217 modified "2023-09-27" @default.
- W2182105217 title "Sensitivity and Specificity of Anti-Cyclic Citrullinated Peptide Antibodies, Compared to Rheumatoid Factor in Syrian Rheumatoid Arthritis Patients" @default.
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