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• W2182111055 abstract "Chronic kidney disease (CKD) is a major public health problem world-wide. Recent professional guidelines classify the severity of CKD into five stages starting with stage 1, being the mildest and usually causing few symptoms, to stage 5, being a severe illness with poor life-expectancy if untreated. CKD is recognized as a common condition that is associated with an increased risk of cardiovascular disease and chronic renal failure (CRF). A number of promising markers that help in assessing the progression of CKD are now available as they help to implement potentially effective therapies in a timely manner. Pentraxin 3 (PTX3) is a 40.6 Kd protein that belongs to the pentraxin super family of multifunctional conserved proteins. It is expressed at a low level in some tissues including the kidney. PTX3 is synthesized systemically in response to kidney damage, followed by glomerular filtration and tubular uptake, and it could be produced locally by injured tubules. PTX3 is also identified in vascular endothelial cells (ECs) and monocytes. Human peripheral blood monocytes express significant levels of PTX3 in response to the pro-inflammatory cytokines. PTX3 is rapidly produced from the cells involved in atherosclerotic lesions, namely vascular endothelial cells, vascular smooth muscle cells, macrophages, and neutrophils in response to inflammatory stimuli. In order to evaluate the clinical utility of PTX3 in chronic kidney disease as well as its association with cardiovascular diseases (CVD). Plasma PTX3 levels were measured in 50 adult patients with CKD (stages 3-5 based on estimated glomerular filtration rate (eGFR) by modification of diet in renal disease (MDRD) study equation) divided into two groups: Group 1(Stages 3-4) and Group 2: (Stage 5). Each group was subdivided into two groups according to presence or absence of cardiovascular diseases (CVD). Twenty apparently healthy age- and sex-matched subjects served as a control group. Assay was carried out using an ELISA technique, and results were expressed as ng/mL. Furthermore, kidney function tests (BUN, creatinine, eGFR & calculated GFR), lipid profile (total cholesterol &triglycerides) as well as CRP were also measured. Plasma PTX3 showed a highly significant increase in CKD patients collectively as compared to healthy controls. There was also a highly significant stepwise progressive increase in PTX3 levels from stage 3 through stage 5 indicating that PTX3 is a marker of disease progression. PTX3 levels were also significantly higher in CKD patients with CVD when compared to those without CVD indicating that PTX3 increases in CVD independent of CKD. Conclusion: Plasma PTX3 is a promising independent diagnostic marker for identifying patients with CKD as well as it is proposed as a useful indicator of disease progression. Increased plasma level of PTX3 may accelerate the vascular complications in CKD, in addition plasma PTX3 in conjunction with serum CRP can help in differentiation between CKD patients with CVD from those without CVD. Aim of the Work: The aim of the present study is to evaluate the plasma levels of pentraxin 3 (PTX3) in patients with chronic kidney disease as a diagnostic and prognostic biomarker and compare its levels with other inflammatory markers as CRP and the possible association of PTX3 with cardiovascular disease in these patients." @default.
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• W2182111055 date "2013-01-01" @default.
• W2182111055 modified "2023-09-24" @default.
• W2182111055 title "Plasma pentraxin-3 level as a biomarker in patients with Chronic Kidney Disease and its Association with Cardiovascular complications" @default.
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