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- W2182123495 abstract "PURPUSE: The aim of this study was to investigate whether -308 G/A TNFA polymorphism (rs1800629) enables development of SLE in Bulgarian population. METHODS: Genotyping for rs1800629 polymorphism was performed by restriction fragment length polymorphisms-PCR assay. A total of 86 SLE patients were compared with 83 healthy subjects. RESULTS: There was an increase of the TNFA -308 A allele (21.5% vs 9%) and decrease of the TNFA -308 G allele in cases versus controls (78.5% vs 91%; p=0.001). We found a lower frequency of GG genotype (57% vs 81.9%) and a higher frequency of heterozygous AG genotype (43% vs 18%) in SLE patients compared to healthy individuals (p<0.001). Logistic regression analysis revealed that the presence of TNFA -308 A allele in the genotype was associated with 3.4 times higher risk of developing SLE (OR=3.423; p<0.001). Moreover, we observed that the carriers of the GG-genotype are protected from development of neuropsychiatric lupus (OR=0.224; p=0.048) and simultaneously have an elevated risk for hematological abnormalities (OR=2.5; p=0.086). CONCLUSIONS: Our results shown that TNFA rs1800629 gene polymorphism is associated with susceptibility and appearance of certain clinical manifestations of this autoimmune disease. The importance of TNFA in SLE development could be useful for establishing current management strategies with biological agents." @default.
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- W2182123495 date "2014-01-01" @default.
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- W2182123495 title "Association of -308 G/A TNFA polymorphism with systemic lupus erythematosus: A preliminary study" @default.
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