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- W2182135039 abstract "In this study, we investigated the presence of a high incidence of common mitochondrial deletion in mtDNA of colon cancer tissues and in blood of both patients and control samples. For this purpose, one of the common regions of the mitochondrial genome was screened using different techniques including PCR amplification, Southern blot, and real-time PCR followed by DNA sequence analysis. Isolated DNA was applied for amplification of hypervariable regions ATPase8/6, COXIII, ND3, ND4, and ND5 of delta mtDNA4977. In 25 colon cancer patients, delta mtDNA4977 was identified using quantitative RTPCR in 6 cases (4.5%) of the tumoral tissues and 18 cases (4.47%) of the non-tumoral tissues that were adjacent to the tumors. Delta mtDNA4977 was detected more in non-tumoral tissues than in adjacent tumoral tissues, but less common deletion was observed (0.017%). Additionally, no 4,977-bp common mitochondrial deletion was observed in blood of patients and 100 control samples. Unknown genetic aspects, ambiguous environmental factors, and reactive oxygen species (ROS) are events that cause the delta mtDNA4977 mutation rate to be elevated more in non-tumoral tissues as compared to adjacent tumoral tissues of colon cancer. The results of our study propose that delta mtDNA4977 percentage in tumoral tissue is less prevalent and is untolerable, perhaps due to high metabolism and ROS production." @default.
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- W2182135039 date "2013-01-01" @default.
- W2182135039 modified "2023-09-27" @default.
- W2182135039 title "Pitfall of Real-Time PCR Method to Find Delta mtDNA in Colon Cancer" @default.
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