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- W2182152304 abstract "Spike-triggered spreading depression (STSD) waves can be elicited from the penicillin focus in the cerebral cortex of rats by the first spike appearing after an interruption (>30 sec) of the interictal discharge, caused by postictal suppression or by spreading depression (SD). STSD incidence is markedly increased by administration of BW 58-271 (2 methyl 4 benzoyl- amino-pyrrolo/2, 3-d/pyri- midine). At doses (5—10 mg/kg) which do not elicit spontaneous SD waves in locally anaesthetized curarized rats, STSD waves appear not only in the penicillin focus but also in the thalamus and caudate nucleus. Pentobarbital anaesthesia blocks the projected STSD waves without interfering with their generation in the focus. BW 58-271 increased the success of STSD induction from 17% to 58 % in rats under pentobarbital anaesthesia and allowed thus systematic examination of the conditions for STSD continuation or termination. Sequences of up to 20 STSD waves were generated at 6—8 min intervals when the SD elicited suppression of the interictal discharge outlasted the period of SD refractoriness. The STSD sequence was terminated when repetitive penicillin spikes were triggered by electrical stimulation or by projected discharge during SD refractoriness. Frequent interictal activity prevented STSD generation by increasing the potassium clear ance in the activated tissue. Repetitive STSD waves are an example of a slow periodic process generated by complex interaction of synaptic, neurohumoral and metabolic influences." @default.
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- W2182152304 date "1983-01-01" @default.
- W2182152304 modified "2023-10-03" @default.
- W2182152304 title "Spike-Triggered Spreading Depression: Facilitation by Pyrrolopyrimi dine" @default.
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