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• W2182154268 abstract "Amyloid deposits are a characteristic feature of advanced Alzheimer dementia (AD), but whether they initiate the disease or are a consequence of it remains an unsettled question. To explore an alternative pathogenic mechanism, I propose that the triggering events that begin the pathogenic cascade are not amyloid deposits but damaged blood vessels caused by inflammatory reactions that lead to ischemia, amyloid accumulation, axonal degeneration, synaptic loss, and eventually irreversible neuronal cell death. Inflammation and blood vessel damage are well recognized complications of AD, but what causes them and why the cerebral microvasculature is affected have never been adequately addressed. Because heritable autosomal dominant mutations of NLRP3, APP, TREX1, NOTCH3, and Col4A1 are known to provoke inflammatory reactions and damage the brain in a wide variety of diseases, I propose that one or more low abundant, gain-of-function somatic mutations of the same 5 gene families damage the microvasculature of the brain that leads to dementia. This implies that the pathogenic triggers that lead to AD are derived not from external invaders or amyloid but from oxidative damage of our own genes." @default.
• W2182154268 created "2016-06-24" @default.
• W2182154268 creator A5077342172 @default.
• W2182154268 date "2015-11-02" @default.
• W2182154268 modified "2023-10-13" @default.
• W2182154268 title "Gain‐of‐function somatic mutations contribute to inflammation and blood vessel damage that lead to Alzheimer dementia: a hypothesis" @default.
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• W2182154268 doi "https://doi.org/10.1096/fj.15-282285" @default.
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