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- W2182189596 abstract "Current differential correlation methods are designed to determine molecular feature pairs that have the largest magnitude of difference between correlation coefficients. These methods do not easily capture molecular feature pairs that experience no correlation in one group but correlation in another, which may reflect certain types of biological interactions. We have developed a tool, the Discordant method, which categorizes the correlation types for each group to make this possible.We compare the Discordant method to existing approaches using simulations and two biological datasets with different types of -omics data. In contrast to other methods, Discordant identifies phenotype-related features at a similar or higher rate while maintaining reasonable computational tractability and usability.R code and sample data are available at https://github.com/siskac/discordantkaterina.kechris@ucdenver.eduSupplementary data are available at Bioinformatics online." @default.
- W2182189596 created "2016-06-24" @default.
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- W2182189596 date "2015-10-31" @default.
- W2182189596 modified "2023-10-12" @default.
- W2182189596 title "The discordant method: a novel approach for differential correlation" @default.
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- W2182189596 doi "https://doi.org/10.1093/bioinformatics/btv633" @default.
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