FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182192687> ?p ?o ?g. }

• W2182192687 endingPage "7" @default.
• W2182192687 startingPage "652" @default.
• W2182192687 abstract "Neutrophil granulocytes play a key role in the pathogenesis of a wide variety of pulmonary diseases. In many such conditions, the injury observed reflects the activation status rather than the total number of inflammatory cells present. The metabolic activity of neutrophils can now be assessed noninvasively using PET to measure the regional uptake of (18)F-FDG after intravenous injection.To understand the mechanism responsible for the increased (18)F-FDG signal, we have measured the uptake of tritiated deoxyglucose (DG) in neutrophils isolated from human peripheral blood and sought to determine which aspects of neutrophil function correlate with an increase in DG uptake.Our results show that formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated respiratory burst activity and (3)H-DG uptake are temporally dissociated, that neutrophil-priming agents such as tumor necrosis factor-alpha (TNFalpha) cause an identical increase in (3)H-DG uptake compared with fMLP without affecting respiratory burst activity, and that fMLP stimulation of TNFalpha-primed cells causes major upregulation of superoxide anion generation (O(2)(-)) yet no incremental increase in (3)H-DG uptake. Furthermore, direct activation of reduced nicotinamide adenine dinucleotide phosphate oxidase activity with the ester phorbol 12-myristate 13-acetate resulted in a concentration-dependent loss of cell-associated (3)H-DG, and preincubation of neutrophils with the phosphoinositide 3-kinase inhibitor wortmannin, which abolished both agonist-stimulated superoxide anion generation and degranulation, had no effect on TNFalpha- or fMLP-stimulated (3)H-DG uptake. In contrast, the fMLP-stimulated change in neutrophil shape was not influenced by priming or wortmannin, and of the functional responses examined, this appeared to correlate most closely with (3)H-DG uptake.DG uptake occurs in both primed and activated neutrophils. It does not correlate with respiratory burst or secretory activity but may reflect the polarization and migrational status of these cells. These data have important implications for the analysis of (18)F-FDG signals in vivo." @default.
• W2182192687 created "2016-06-24" @default.
• W2182192687 creator A5007389587 @default.
• W2182192687 creator A5019872367 @default.
• W2182192687 creator A5023438237 @default.
• W2182192687 creator A5048100194 @default.
• W2182192687 creator A5069889145 @default.
• W2182192687 creator A5078127523 @default.
• W2182192687 date "2002-05-01" @default.
• W2182192687 modified "2023-10-03" @default.
• W2182192687 title "Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of (18)F-FDG PET images." @default.
• W2182192687 cites W1500276200 @default.
• W2182192687 cites W1512168529 @default.
• W2182192687 cites W1548377812 @default.
• W2182192687 cites W1563659500 @default.
• W2182192687 cites W1631483568 @default.
• W2182192687 cites W1818313483 @default.
• W2182192687 cites W1921676257 @default.
• W2182192687 cites W1972114259 @default.
• W2182192687 cites W1994168320 @default.
• W2182192687 cites W200450889 @default.
• W2182192687 cites W2010465546 @default.
• W2182192687 cites W2018744199 @default.
• W2182192687 cites W2023036503 @default.
• W2182192687 cites W2044187133 @default.
• W2182192687 cites W2087820683 @default.
• W2182192687 cites W2090306035 @default.
• W2182192687 cites W2091495664 @default.
• W2182192687 cites W2097389043 @default.
• W2182192687 cites W2148788956 @default.
• W2182192687 cites W317349470 @default.
• W2182192687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11994530" @default.
• W2182192687 hasPublicationYear "2002" @default.
• W2182192687 type Work @default.
• W2182192687 sameAs 2182192687 @default.
• W2182192687 citedByCount "44" @default.
• W2182192687 countsByYear W21821926872012 @default.
• W2182192687 countsByYear W21821926872013 @default.
• W2182192687 countsByYear W21821926872014 @default.
• W2182192687 countsByYear W21821926872015 @default.
• W2182192687 countsByYear W21821926872016 @default.
• W2182192687 countsByYear W21821926872017 @default.
• W2182192687 countsByYear W21821926872018 @default.
• W2182192687 countsByYear W21821926872019 @default.
• W2182192687 countsByYear W21821926872022 @default.
• W2182192687 countsByYear W21821926872023 @default.
• W2182192687 crossrefType "journal-article" @default.
• W2182192687 hasAuthorship W2182192687A5007389587 @default.
• W2182192687 hasAuthorship W2182192687A5019872367 @default.
• W2182192687 hasAuthorship W2182192687A5023438237 @default.
• W2182192687 hasAuthorship W2182192687A5048100194 @default.
• W2182192687 hasAuthorship W2182192687A5069889145 @default.
• W2182192687 hasAuthorship W2182192687A5078127523 @default.
• W2182192687 hasConcept C126322002 @default.
• W2182192687 hasConcept C134018914 @default.
• W2182192687 hasConcept C170493617 @default.
• W2182192687 hasConcept C17991360 @default.
• W2182192687 hasConcept C181199279 @default.
• W2182192687 hasConcept C185592680 @default.
• W2182192687 hasConcept C203014093 @default.
• W2182192687 hasConcept C24998067 @default.
• W2182192687 hasConcept C2777983669 @default.
• W2182192687 hasConcept C2777989768 @default.
• W2182192687 hasConcept C2780795997 @default.
• W2182192687 hasConcept C38485361 @default.
• W2182192687 hasConcept C49802076 @default.
• W2182192687 hasConcept C55493867 @default.
• W2182192687 hasConcept C71924100 @default.
• W2182192687 hasConcept C86803240 @default.
• W2182192687 hasConcept C99971728 @default.
• W2182192687 hasConceptScore W2182192687C126322002 @default.
• W2182192687 hasConceptScore W2182192687C134018914 @default.
• W2182192687 hasConceptScore W2182192687C170493617 @default.
• W2182192687 hasConceptScore W2182192687C17991360 @default.
• W2182192687 hasConceptScore W2182192687C181199279 @default.
• W2182192687 hasConceptScore W2182192687C185592680 @default.
• W2182192687 hasConceptScore W2182192687C203014093 @default.
• W2182192687 hasConceptScore W2182192687C24998067 @default.
• W2182192687 hasConceptScore W2182192687C2777983669 @default.
• W2182192687 hasConceptScore W2182192687C2777989768 @default.
• W2182192687 hasConceptScore W2182192687C2780795997 @default.
• W2182192687 hasConceptScore W2182192687C38485361 @default.
• W2182192687 hasConceptScore W2182192687C49802076 @default.
• W2182192687 hasConceptScore W2182192687C55493867 @default.
• W2182192687 hasConceptScore W2182192687C71924100 @default.
• W2182192687 hasConceptScore W2182192687C86803240 @default.
• W2182192687 hasConceptScore W2182192687C99971728 @default.
• W2182192687 hasIssue "5" @default.
• W2182192687 hasLocation W21821926871 @default.
• W2182192687 hasOpenAccess W2182192687 @default.
• W2182192687 hasPrimaryLocation W21821926871 @default.
• W2182192687 hasRelatedWork W1597477855 @default.
• W2182192687 hasRelatedWork W1967603706 @default.
• W2182192687 hasRelatedWork W1972523888 @default.
• W2182192687 hasRelatedWork W2005714929 @default.
• W2182192687 hasRelatedWork W2084275909 @default.
• W2182192687 hasRelatedWork W2163993168 @default.
• W2182192687 hasRelatedWork W2182192687 @default.

• next