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• W2182221722 abstract "LH-Stimulated steroid production was studied in vitro in Leydig cells isolated from testes of 26, 32, 44, 54, and 64-day-old rats treated with estradiol implants. Five days after implantation of estradiol, the maximal testosterone production was decreased in 32, 44, 52, and 64-day-old rats, while maximal � -pregnenolone production was not changed. In 26-day-old rats, however, production rates of both testosterone and � -pregnenolone were decreased. The estradiol effect on testosterone production could be observed 48 h after implantation. Testosterone treatment for 5 days resulted in decreased testosterone as well as t� -pregnenolone production. Corticosterone implants were without effect. In contrast to the decrease in the maximal response with respect to testosterone production after estradiol treatment, a fivefold increase was observed in the sensitivity of Leydig cells for LH with respect to t� -pregnenolone and testosterone production. Administration of estradiol to 32-day-old rats resulted in decreased testicular levels of microsomal cytochrome P450 and in the formation of 3a-hydroxy-5o-pregnan-20-one. In Leydig cells from hypophysectomized 64-day-old rats treated for 5 days with estradiol, a decrease in C17_20-lyase and 17o-hydroxylasc activity was found. It is concluded that the observed decrease in testosterone production by Leydig cells from rats treated in vivo with estradiol is the consequence of a specific action of estradiol on testicular microsomal enzymes (including 1 7o-hydroxylase, C,7 -20 -lyase and cytochrome P450)." @default.
• W2182221722 created "2016-06-24" @default.
• W2182221722 creator A5020975434 @default.
• W2182221722 date "1980-11-01" @default.
• W2182221722 modified "2023-09-25" @default.
• W2182221722 title "A Specific Action of Estradiol on Enzymes Involved in Testicular Steroidogenesis" @default.
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• W2182221722 doi "https://doi.org/10.1095/biolreprod23.4.801" @default.
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