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- W2182231205 abstract "We explored the effect of leukotriene B4 (LTB4) on endothelial cells in LTB4-induced transen- dothelial migration (TEM) ofneutrophils as an in vitro model of neutrophil extravasation. Chemotactic re- sponse of human neutrophils to LTB4 was significantly lower than that in response to N-formyl-methionyl- leucyl-phenylalanine (fMLP), whereas the extent of ThM in response to LTB4 was significantly higher than that to fMLP. The study on random migration induced by LTB4 and fMLP also showed similar results, which indicated that LTB4 might affect the human umbili- cal cord vein endothelial cell (HUVEC) barrier. Neutro- phil TEM was induced by pretreatment of HUVEC monolayer with LTB4 but not with fMLP. Treatment of endothelial cells by ONO-4057, a LTB4 recep- tor antagonist, abolished the effect of LTB4 almost completely whereas neutrophils treated with ONO- 4057 could transnilgrate through HUVEC treated with LTB4. These findings indicated that LTB4 could in- duce neutrophil TEM by acting on HUVEC. J. Leu- koc. Biol. 62: 203-209; 1997." @default.
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- W2182231205 date "1997-01-01" @default.
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- W2182231205 title "transendothelial neutrophil migration" @default.
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