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• W2182248001 abstract "Recently, a renewed interest towards development of new antibacterial agents has been created due to emergence of newer pathogenic bacterial strains showing high resistance to such agents. There has also been a decline in research by medical and pharmaceutical companies in last decade which has caused a shortfall in developing newer agents to fight present threat of drug resistance. Hence, there is continuous need to develop newer antibiotics that interact with essential mechanisms in bacteria. Recently, the enzymes responsible for biosynthesis of the essential amino acid lysine in plants, bacteria and fungi have been targeted and it has augmented interest to develop novel antibiotic compounds and to enhance lysine yields in over-producing organisms. Diaminopimelate (DAP) pathway in bacteria for biosynthesis of lysine and its immediate precursor meso-DAP have been represented as novel targets, both of which play a major role in cross-linking of peptidoglycan layer of microbial cell wall. Lysine is a constituent in gram-positive bacteria while gram-negative bacteria contain meso-DAP. Substrate-based inhibitors of enzymes in the DAP pathway have been reviewed and inhibitors that allow better understanding of the enzymology of the targets and provide insight for the design of new inhibitors have been discussed in this article. Synthetic enzyme inhibitors of the DAP pathway with appropriate substrate-based analog have been found to be more effective against resistant bacterial strains and less toxic to mammals. The enzymes involved in this pathway may be viable targets and shall be supportive to develop novel antimicrobial drugs." @default.
• W2182248001 created "2016-06-24" @default.
• W2182248001 creator A5079390639 @default.
• W2182248001 creator A5089919111 @default.
• W2182248001 date "2014-01-01" @default.
• W2182248001 modified "2023-09-22" @default.
• W2182248001 title "Exploration of Lysine Pathway for Developing Newer Anti-Microbial Analogs through Enzyme Inhibition Approach" @default.
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