Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182275265> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2182275265 endingPage "737" @default.
- W2182275265 startingPage "733" @default.
- W2182275265 abstract "In Behcet’s disease (BD), interleukin (IL)-6 drive the immune-mediated inflammatory process. The IL-6 receptor can be targeted using tocilizumab. As an off-label treatment, we tested its efficacy in patients with BD. Overall, 4 patients with refractory BD were treated with tocilizumab, 8 mg/kg/4 weeks. Patients were clinically and biologically assessed before administering each dose and the literature was reviewed. Tocilizumab was found to be safe and well tolerated. BD activity decreased significantly in all patients, and prednisone dose was reduced in all cases (up to 50% of the baseline dose). Treatment appeared effective in alleviating skin/mucosal effects, neurological involvement, and uveitis, but less effective for arthralgia and abdominal pain. A very short time lag between the onset of treatment with tocilizumab and the clinical response was observed. The literature review revealed 11 previous cases reporting improvement to BD with this treatment, and 3 previous cases without efficacy. We reported the most important study treating refractory BD with tocilizumab; this treatment could be safe and efficient, but will require further evaluation by randomized clinical trials." @default.
- W2182275265 created "2016-06-24" @default.
- W2182275265 creator A5016356458 @default.
- W2182275265 creator A5045287052 @default.
- W2182275265 creator A5068345425 @default.
- W2182275265 date "2016-06-01" @default.
- W2182275265 modified "2023-10-06" @default.
- W2182275265 title "Tocilizumab in severe and refractory Behcet’s disease: Four cases and literature review" @default.
- W2182275265 cites W1972240373 @default.
- W2182275265 cites W2019323646 @default.
- W2182275265 cites W2023761225 @default.
- W2182275265 cites W2027738506 @default.
- W2182275265 cites W2041820432 @default.
- W2182275265 cites W2044277598 @default.
- W2182275265 cites W2049882606 @default.
- W2182275265 cites W2055026612 @default.
- W2182275265 cites W2063485775 @default.
- W2182275265 cites W2099496753 @default.
- W2182275265 cites W2107280923 @default.
- W2182275265 cites W2114973121 @default.
- W2182275265 cites W2116159806 @default.
- W2182275265 cites W2124301140 @default.
- W2182275265 cites W2142258588 @default.
- W2182275265 cites W2143190437 @default.
- W2182275265 cites W2150900575 @default.
- W2182275265 cites W2155779547 @default.
- W2182275265 cites W4232001057 @default.
- W2182275265 doi "https://doi.org/10.1016/j.semarthrit.2015.11.012" @default.
- W2182275265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26743073" @default.
- W2182275265 hasPublicationYear "2016" @default.
- W2182275265 type Work @default.
- W2182275265 sameAs 2182275265 @default.
- W2182275265 citedByCount "52" @default.
- W2182275265 countsByYear W21822752652016 @default.
- W2182275265 countsByYear W21822752652017 @default.
- W2182275265 countsByYear W21822752652018 @default.
- W2182275265 countsByYear W21822752652019 @default.
- W2182275265 countsByYear W21822752652020 @default.
- W2182275265 countsByYear W21822752652021 @default.
- W2182275265 countsByYear W21822752652022 @default.
- W2182275265 countsByYear W21822752652023 @default.
- W2182275265 crossrefType "journal-article" @default.
- W2182275265 hasAuthorship W2182275265A5016356458 @default.
- W2182275265 hasAuthorship W2182275265A5045287052 @default.
- W2182275265 hasAuthorship W2182275265A5068345425 @default.
- W2182275265 hasConcept C121332964 @default.
- W2182275265 hasConcept C126322002 @default.
- W2182275265 hasConcept C142424586 @default.
- W2182275265 hasConcept C203014093 @default.
- W2182275265 hasConcept C2776194053 @default.
- W2182275265 hasConcept C2777178219 @default.
- W2182275265 hasConcept C2778720950 @default.
- W2182275265 hasConcept C2779134260 @default.
- W2182275265 hasConcept C2781428731 @default.
- W2182275265 hasConcept C71924100 @default.
- W2182275265 hasConcept C87355193 @default.
- W2182275265 hasConcept C90924648 @default.
- W2182275265 hasConceptScore W2182275265C121332964 @default.
- W2182275265 hasConceptScore W2182275265C126322002 @default.
- W2182275265 hasConceptScore W2182275265C142424586 @default.
- W2182275265 hasConceptScore W2182275265C203014093 @default.
- W2182275265 hasConceptScore W2182275265C2776194053 @default.
- W2182275265 hasConceptScore W2182275265C2777178219 @default.
- W2182275265 hasConceptScore W2182275265C2778720950 @default.
- W2182275265 hasConceptScore W2182275265C2779134260 @default.
- W2182275265 hasConceptScore W2182275265C2781428731 @default.
- W2182275265 hasConceptScore W2182275265C71924100 @default.
- W2182275265 hasConceptScore W2182275265C87355193 @default.
- W2182275265 hasConceptScore W2182275265C90924648 @default.
- W2182275265 hasIssue "6" @default.
- W2182275265 hasLocation W21822752651 @default.
- W2182275265 hasLocation W21822752652 @default.
- W2182275265 hasOpenAccess W2182275265 @default.
- W2182275265 hasPrimaryLocation W21822752651 @default.
- W2182275265 hasRelatedWork W2170111382 @default.
- W2182275265 hasRelatedWork W2297848937 @default.
- W2182275265 hasRelatedWork W2417066483 @default.
- W2182275265 hasRelatedWork W2588375059 @default.
- W2182275265 hasRelatedWork W2919462106 @default.
- W2182275265 hasRelatedWork W3030691326 @default.
- W2182275265 hasRelatedWork W3089633195 @default.
- W2182275265 hasRelatedWork W4229528624 @default.
- W2182275265 hasRelatedWork W4239487355 @default.
- W2182275265 hasRelatedWork W4283731973 @default.
- W2182275265 hasVolume "45" @default.
- W2182275265 isParatext "false" @default.
- W2182275265 isRetracted "false" @default.
- W2182275265 magId "2182275265" @default.
- W2182275265 workType "article" @default.