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- W2182278665 abstract "In this research program, the synthesis and pharmacological evaluation of two novel derivatives of Piperidine-4-carboxamide, 1-(3,5-dinitrobenzoyl)piperidine-4-carboxamide (I) and 1-(3,4,5trimethoxybenzoyl)piperidine-4-carboxamide (II) were reported. They were synthesized by condensing the parent molecule with substituted benzoyl chlorides. The structural elucidation of these newly synthesized derivatives was performed using UV Visible, IR, 1HNMR, EIMS. The products were then assessed on different pharmacological parameters such as analgesic, antimicrobial, antioxidant, and anxiolytic activities. It was observed that compound II displayed good analgesic profile. Both compounds possessed least to moderate antibacterial effects against tested strains of gram positive and gram negative bacteria. Compound I expressed moderate antifungal activity against some filamentous fungi and yeast while compound II possessed least activity for fungi only. Both compounds were inactive as antioxidants and also failed to produce remarkable change in behavior at the dose 50mg/Kg body weight. SAR was also established." @default.
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- W2182278665 date "2014-01-01" @default.
- W2182278665 modified "2023-09-26" @default.
- W2182278665 title "SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL BENZOYL DERIVATIVES OF PIPERIDINE-4-CARBOXAMIDE" @default.
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