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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182280263> ?p ?o ?g. }

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• W2182280263 abstract "In renal cell carcinoma (RCC), glycosphingolipids monosialosyl globopentaosylceramide (MSGb5) and GalNAc disialosyl lactotetraosylceramide (GaINAcDSLc4) were shown to be predictors of metastasis. Here we extended the research using a larger cohort of patients with a longer follow-up period, and reevaluate their relationship to malignant potential, metastasis and prognosis in patients with RCC.MSGb5 and GalNAcDSLc4 were examined in 114 primary RCCs by immunohistochemical method on cryostat sections.GalNAcDSLc4 was detected in 13.2% of RCCs and was associated with a significantly higher incidence of metastasis at the time of primary visit (60.0% vs. 31.3%, p=0.0419) as well as de novo metastasis during followup (33.3% vs. 14.7%), and a shorter survival (p=0.0399). MSGb5 was detected in 51.8% of tumors and was not related to clinocopathological characteristics or survival.RCC patients with tumors positive for GalNAcDSLc4 are at higher risk of metastasis at the time of diagnosis and during follow-up." @default.
• W2182280263 created "2016-06-24" @default.
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• W2182280263 date "2008-01-25" @default.
• W2182280263 modified "2023-09-27" @default.
• W2182280263 title "High incidence of GalNAc disialosyl lactotetraosylceramide in metastatic renal cell carcinoma." @default.
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• W2182280263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18214042" @default.
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