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- W2182305604 abstract "Ovarian cancer is the fifth most common female cancer in the Western world, and the deadliest gynecological malignancy. The overall poor prognosis for ovarian cancer patients is a consequence of aggressive biological behavior and a lack of adequate diagnostic tools for early detection. In fact, approximately 70% of all patients with epithelial ovarian cancer are diagnosed at advanced tumor stages. These facts highlight a significant clinical need for reliable and accurate detection methods for ovarian cancer, especially for patients at high risk. Because CA125 has not achieved satisfactory sensitivity and specificity in detecting ovarian cancer, numerous efforts, including those based on single and combined molecule detection and omics approaches, have been made to identify new biomarkers. Intriguingly, more than 10% of all ovarian cancer cases are of familial origin. BRCA1 and BRCA2 germline mutations are the most common genetic defects underlying hereditary ovarian cancer, which is why ovarian cancer risk assessment in developed countries, aside from pedigree analysis, relies on genetic testing of BRCA1 and BRCA2. Because not only BRCA1 and BRCA2 but also other susceptibility genes are tightly linked with ovarian cancer-specific DNA repair defects, another possible approach for defining susceptibility might be patient cell-based functional testing, a concept for which support came from a recent case-control study. This principle would be applicable to risk assessment and the prediction of responsiveness to conventional regimens involving platinum-based drugs and targeted therapies involving poly (ADP-ribose) polymerase (PARP) inhibitors." @default.
- W2182305604 created "2016-06-24" @default.
- W2182305604 creator A5003096205 @default.
- W2182305604 creator A5007459786 @default.
- W2182305604 creator A5011522071 @default.
- W2182305604 creator A5073426374 @default.
- W2182305604 date "2013-01-01" @default.
- W2182305604 modified "2023-09-27" @default.
- W2182305604 title "Ovarian Cancer: In Search of Better Marker Systems Based on" @default.
- W2182305604 cites W1523531555 @default.
- W2182305604 cites W1538419182 @default.
- W2182305604 cites W1545920983 @default.
- W2182305604 cites W1597602644 @default.
- W2182305604 cites W1787878270 @default.
- W2182305604 cites W1839238574 @default.
- W2182305604 cites W1879187490 @default.
- W2182305604 cites W1912177776 @default.
- W2182305604 cites W1928099527 @default.
- W2182305604 cites W1961928411 @default.
- W2182305604 cites W1973037195 @default.
- W2182305604 cites W1973268287 @default.
- W2182305604 cites W1975269858 @default.
- W2182305604 cites W1976648221 @default.
- W2182305604 cites W1976731741 @default.
- W2182305604 cites W1980141308 @default.
- W2182305604 cites W1981816841 @default.
- W2182305604 cites W1984431444 @default.
- W2182305604 cites W1987977690 @default.
- W2182305604 cites W1989587024 @default.
- W2182305604 cites W1991001048 @default.
- W2182305604 cites W1994948218 @default.
- W2182305604 cites W1996889313 @default.
- W2182305604 cites W1999659306 @default.
- W2182305604 cites W2002962154 @default.
- W2182305604 cites W2005113216 @default.
- W2182305604 cites W2009007206 @default.
- W2182305604 cites W2013303121 @default.
- W2182305604 cites W2013743651 @default.
- W2182305604 cites W2014136169 @default.
- W2182305604 cites W2014447135 @default.
- W2182305604 cites W2014606320 @default.
- W2182305604 cites W2015240005 @default.
- W2182305604 cites W2016278235 @default.
- W2182305604 cites W2017801815 @default.
- W2182305604 cites W2018691707 @default.
- W2182305604 cites W2022207080 @default.
- W2182305604 cites W2023353541 @default.
- W2182305604 cites W2024264346 @default.
- W2182305604 cites W2024667952 @default.
- W2182305604 cites W2024694676 @default.
- W2182305604 cites W2026256230 @default.
- W2182305604 cites W2030093162 @default.
- W2182305604 cites W2031142206 @default.
- W2182305604 cites W2032889307 @default.
- W2182305604 cites W2034373652 @default.
- W2182305604 cites W2036179093 @default.
- W2182305604 cites W2037325146 @default.
- W2182305604 cites W2039555878 @default.
- W2182305604 cites W2041205258 @default.
- W2182305604 cites W2042028209 @default.
- W2182305604 cites W2049155850 @default.
- W2182305604 cites W2052729815 @default.
- W2182305604 cites W2053521827 @default.
- W2182305604 cites W2053844006 @default.
- W2182305604 cites W2055344345 @default.
- W2182305604 cites W2056068434 @default.
- W2182305604 cites W2056816232 @default.
- W2182305604 cites W2056848326 @default.
- W2182305604 cites W2059000312 @default.
- W2182305604 cites W2060084956 @default.
- W2182305604 cites W2062006818 @default.
- W2182305604 cites W2062856589 @default.
- W2182305604 cites W2063695656 @default.
- W2182305604 cites W2064293929 @default.
- W2182305604 cites W2064553939 @default.
- W2182305604 cites W2064675975 @default.
- W2182305604 cites W2068989573 @default.
- W2182305604 cites W2070201223 @default.
- W2182305604 cites W2070742943 @default.
- W2182305604 cites W2071966564 @default.
- W2182305604 cites W2072755146 @default.
- W2182305604 cites W2072942199 @default.
- W2182305604 cites W2075930643 @default.
- W2182305604 cites W2079671397 @default.
- W2182305604 cites W2080203245 @default.
- W2182305604 cites W2083613827 @default.
- W2182305604 cites W2083870688 @default.
- W2182305604 cites W2085755265 @default.
- W2182305604 cites W2087409742 @default.
- W2182305604 cites W2088374322 @default.
- W2182305604 cites W2088880249 @default.
- W2182305604 cites W2090116556 @default.
- W2182305604 cites W2091114184 @default.
- W2182305604 cites W2092437373 @default.
- W2182305604 cites W2093832370 @default.
- W2182305604 cites W2095554670 @default.
- W2182305604 cites W2095909899 @default.
- W2182305604 cites W2096136751 @default.
- W2182305604 cites W2096335059 @default.
- W2182305604 cites W2096380982 @default.