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- W2182331988 abstract "The immune systems of patients with urgent surgical pathology are affected by multiple damaging factors. The action of these factors leads to the formation of separate clusters, with centres at points corresponding to optimal characteristics of the immune system. The distance from the centre of the cluster (DC) is closely related to the patient. Were examined 442 patients with urgent abdominal pathology. Using the numbers of CD3+, CD4+, CD8+ and CD16+ lymphocytes, we allocated six clusters of immune status. Depending on the value of DC in each cluster, four quartiles were identified. The results show similar features of relationships between indicators in peripheral and central areas of the clusters as evidence of general principles of organization in different clusters. The peripheral areas of the clusters are characterized by high values of indicators of toxicity and severity of the condition and the greatest values of intensity for immune system and autonomic regulation. Cluster membership and DC are important criteria for evaluating the severity of the patient's condition and to optimize treatment methods." @default.
- W2182331988 created "2016-06-24" @default.
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- W2182331988 date "2013-01-01" @default.
- W2182331988 modified "2023-09-28" @default.
- W2182331988 title "Clusters of Immune System Function in the Clinic: Theory or Unseen Reality?" @default.
- W2182331988 cites W1502823221 @default.
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