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- W2182332494 abstract "Levels of cytokines and GLUT family monosaccharide transporters in the duodenal mu- cosa were examined in patients from Nong Khai, Thailand, who had underwent gastroscopy be- cause of gastrointestinal problems. Duodenal biopsy specimens were collected from a total of 33 patients (24 males and 9 females, 45.0 ± 13.5 years old). Ten patients had present or recent intes- tinal helminth infections, including strongyloidiasis, taeniasis or ascariasis (group A), 7 were urease- test positive, indicating Helicobacter pylori infection (group B), and 16 had neither helminth infec- tions nor urea-test positivity (group C). Total RNA was extracted from the biopsied specimens and a semi-quantitative RT-PCR was performed. The positivities for IL-13, IL-5 and IFN-γ mRNA expres- sions in the patients were 24.2, 60.6 and 100%, respectively, with the highest IL-13 and IL-5 positivities in group A, followed by group C and B. The IL-5 positive rate was significantly higher among pa- tients with high peripheral blood eosinophil counts (>4%) than in patients with low peripheral blood eosinophil counts. GLUT-1 and GLUT-5 were detectable in all the patients. Although GLUT-1 ex- pressions did not differ among groups A, B and C. GLUT-5 expressions were significantly lower in group B than in group C. These results indicate that helminth and H.pylori infections result in differ- ent immunopathological responses in the duodenal mucosa, lower expressions of type 2 cytokines and monosaccharide transporters in H. pylori infections than in helminth infections." @default.
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- W2182332494 date "2005-07-01" @default.
- W2182332494 modified "2023-09-27" @default.
- W2182332494 title "Expression of cytokines and monosaccharide transporters in the duodenal mucosa of patients with gastrointestinal symptoms in rural Thailand." @default.
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