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• W2182421164 abstract "Luiz Carlos Bertges 1, Carlos Alberto Mourao Jr 2, Jonathan Batista Souza 3, Vinicius Antonio Coelho Cardoso 4 1 PhD, Associate Professor at the Physiology Department at UFJF. Professor at SUPREMA. 2 PhD, Assistant Professor at the Physiology Department at UFJF. 3 Physician 4 Physician Institution (Affiliation): Universidade Federal de Juiz de Fora MG Correspondence: Luiz Carlos Bertges, Departamento de Fisiologia, Instituto de Ciencias Biologicas, UFJF, Campus Universitario, Bairro Martelos, Juiz de Fora, MG, CEP 36036900. This article was submitted to SGP (Publication Management System) of Rev Bras Cien Med Health on September 1, 2009. Cod. 37. Accepted on April 27, 2010. Pharmacological relevance: Triton WR1339 (Tyloxapol) has been used by several studies to induce hypercholesterolemia in animals. However, no works in literature were found to clarify the quality and durability of the hypercholesterolemic state. Thus, when studying hypocholesterolemic agents in rats, it is difficult to determine whether the decrease in cholesterol levels resulted from the treatment or from its metabolization throughout the days. Study objective: To determine the cholesterol levels in Wistar rats during the 9 days after the application of Tyloxapol. Materials and methods: Blood samples of 16 rats were collected by venipuncture of the caudal vein for total cholesterol level measurement. A single intraperitoneal dose of Tyloxapol at 200mg/kg was subsequently given. New samples were taken every three days and total cholesterol levels were also measured. Results: Drug action peaked after 72 hours of application, returning to baseline values after that. Conclusion: The induction of hypercholesterolemia by Tyloxapol has shown to be effective in Wistar rats within 72 hours of application of the drug, after that period the results may not reflect the action of cholesterol-lowering agents using this model. ORIGINAL ARTICLE Rev Bras Cien Med Saude. 2011;1(1):32-4." @default.
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• W2182421164 title "Hyperlipidemia induced by Triton WR1339 (Tyloxapol) in Wistar rats" @default.
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