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- W2182468513 abstract "The ABN welcomes the opportunity to respond to this consultation document. We can comment from our role as clinical neurologists rather than health economists. We are very concerned by the proposal to withdraw the previous guidance to recommend the use of cholinesterase inhibitors in mild to moderate Alzheimer’s Disease. We are concerned that the interpretation relies on the use of QALYs which are difficult and unvalidated measures in the area of cognitive impairment. We feel that the emphasis on long-term disease modification is misguided and that more attention should be paid to the undoubted symptomatic benefit shown in the early stages of the disease which has a major impact on the life of the patients and, importantly, their carer-givers. It is the general experience of ABN members that the cholinesterase inhibitors have proved a valuable addition to the management of this important group of patients. Careful assessment and trials of withdrawal of the drugs, where no apparent benefit has been identified, are essential. For those patients who experience significant benefit and in whom that benefit disappears on withdrawal of the drug, this guidance will have major impact. Patients with dementia have long been disadvantaged and dementia management has been associated with therapeutic nihilism. We fear that this recommendation would constitute a major retrograde step. Yours sincerely" @default.
- W2182468513 created "2016-06-24" @default.
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- W2182468513 date "2005-01-01" @default.
- W2182468513 modified "2023-09-27" @default.
- W2182468513 title "Health Technology Appraisal: Alzheimer's disease Donepezil, rivastigmine, galantamine & memantine" @default.
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