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• W2182550242 endingPage "147" @default.
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• W2182550242 abstract "The nucleoside adenosine acts on the nervous and cardiovascular systems via the A2A receptor (A2AR). In response to oxygen level in tissues, adenosine plasma concentration is regulated in particular via its synthesis by CD73 and via its degradation by adenosine deaminase (ADA). The cell-surface endopeptidase CD26 controls the concentration of vasoactive and antioxidant peptides and hence regulates the oxygen supply to tissues and oxidative stress response. Although overexpression of adenosine, CD73, ADA, A2AR, and CD26 in response to hypoxia is well documented, the effects of hyperoxic and hyperbaric conditions on these elements deserve further consideration. Rats and a murine Chem-3 cell line that expresses A2AR were exposed to 0.21 bar O2, 0.79 bar N2 (terrestrial conditions; normoxia); 1 bar O2 (hyperoxia); 2 bar O2 (hyperbaric hyperoxia); 0.21 bar O2, 1.79 bar N2 (hyperbaria). Adenosine plasma concentration, CD73, ADA, A2AR expression, and CD26 activity were addressed in vivo, and cAMP production was addressed in cellulo. For in vivo conditions, 1) hyperoxia decreased adenosine plasma level and T cell surface CD26 activity, whereas it increased CD73 expression and ADA level; 2) hyperbaric hyperoxia tended to amplify the trend; and 3) hyperbaria alone lacked significant influence on these parameters. In the brain and in cellulo, 1) hyperoxia decreased A2AR expression; 2) hyperbaric hyperoxia amplified the trend; and 3) hyperbaria alone exhibited the strongest effect. We found a similar pattern regarding both A2AR mRNA synthesis in the brain and cAMP production in Chem-3 cells. Thus a high oxygen level tended to downregulate the adenosinergic pathway and CD26 activity. Hyperbaria alone affected only A2AR expression and cAMP production. We discuss how such mechanisms triggered by hyperoxygenation can limit, through vasoconstriction, the oxygen supply to tissues and the production of reactive oxygen species." @default.
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• W2182550242 date "2015-07-15" @default.
• W2182550242 modified "2023-10-15" @default.
• W2182550242 title "Effect of hyperoxic and hyperbaric conditions on the adenosinergic pathway and CD26 expression in rat" @default.
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• W2182550242 cites W1790342517 @default.
• W2182550242 cites W1864948096 @default.
• W2182550242 cites W1974989255 @default.
• W2182550242 cites W1979856527 @default.
• W2182550242 cites W1980218345 @default.
• W2182550242 cites W1987534017 @default.
• W2182550242 cites W1990113288 @default.
• W2182550242 cites W1993034847 @default.
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• W2182550242 cites W2003164842 @default.
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• W2182550242 cites W2046467234 @default.
• W2182550242 cites W2052269083 @default.
• W2182550242 cites W2052672198 @default.
• W2182550242 cites W2053482008 @default.
• W2182550242 cites W2054555865 @default.
• W2182550242 cites W2054661897 @default.
• W2182550242 cites W2055665437 @default.
• W2182550242 cites W2055865039 @default.
• W2182550242 cites W2056222368 @default.
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• W2182550242 cites W2062690889 @default.
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• W2182550242 cites W2066417565 @default.
• W2182550242 cites W2075558733 @default.
• W2182550242 cites W2076044363 @default.
• W2182550242 cites W2077119701 @default.
• W2182550242 cites W2083214032 @default.
• W2182550242 cites W2085403057 @default.
• W2182550242 cites W2090368102 @default.
• W2182550242 cites W2091638124 @default.
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• W2182550242 cites W2122153143 @default.
• W2182550242 cites W2126528640 @default.
• W2182550242 cites W2127875836 @default.
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• W2182550242 cites W2145026921 @default.
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• W2182550242 cites W2165291521 @default.
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• W2182550242 cites W2170936621 @default.
• W2182550242 cites W2171383865 @default.
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• W2182550242 doi "https://doi.org/10.1152/japplphysiol.00223.2015" @default.
• W2182550242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25997945" @default.
• W2182550242 hasPublicationYear "2015" @default.
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