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- W2182561886 abstract "Attention-Deficit/Hyperactivity Disorder (ADHD) is recognized as a priority clinical and public health concern because of its prevalence, chronicity, and associated morbidity and impairment in children, adolescents, and adults. It is one of the most common neurobehavioral disorders of childhood with worldwide prevalence rates conservatively estimated at 4–10%. It is also common in adults and in general, it affects more males than females. ADHD is one of the most extensively investigated mental health disorders of childhood and adolescence. Nonetheless, it lacks specific biomarkers and remains underspecified. Moreover, it is undergoing re-conceptualization and the emerging neuroscientific understanding of ADHD challenges current targets for treatment. This chapter provides an update on the clinical and neuroscientific perspectives on ADHD and highlights the historical and current development of pharmacological treatment approaches. It also discusses the potential utility of biomarkers in drug development and the clinical challenges in pursuing novel pharmacological approaches for ADHD, given its primacy as a pediatric disorder." @default.
- W2182561886 created "2016-06-24" @default.
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- W2182561886 date "2008-01-01" @default.
- W2182561886 modified "2023-09-24" @default.
- W2182561886 title "Towards a Biological Understanding of ADHD and the Discovery of Novel Therapeutic Approaches" @default.
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