FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182565720> ?p ?o ?g. }

• W2182565720 endingPage "22" @default.
• W2182565720 startingPage "417" @default.
• W2182565720 abstract "Fractionation of the cyclohexane extract from the stem bark powder of Zanthoxylum madagascariense led to the isolation of a new benzophenanthridine-type alkaloid, hydrochloride of 2,3-methylendioxy-8-hydroxy- 7-methoxy-benzo[C]phenanthridine (Rutaceline), characterized on the basis of its spectral data. Rutaceline was evaluated for its antiproliferative capacity on the human colorectal adenocarcinoma (Caco-2) and the African green monkey kidney (Vero) cell lines. The 50% inhibition of cell growth (IC50) obtained after 24 h incubation was similar for both cells lines (110-115 microg/ml, i.e. 269-281 microM), but at 48 h the IC50 value for the Caco-2 cells was lower than for the Vero cells (20 microg/lml, i.e. 49 microM versus 90 microg/ml, i.e. 220 microM) indicating a higher cell growth inhibitory effect on the colon adenocarcinoma cells. At the respective IC50 concentrations, Rutaceline did not significantly induce apoptosis but induced cell cycle arrest in the GO/G1 phase, as well as a decrease of cells in S phase. Rutaceline also induced DNA fragmentation in both cell lines, as revealed by agarose gel electrophoresis, and a dose-dependent clastogenic effect in both cell lines as revealed by the Comet assay." @default.
• W2182565720 created "2016-06-24" @default.
• W2182565720 creator A5023939276 @default.
• W2182565720 creator A5027349537 @default.
• W2182565720 creator A5041989247 @default.
• W2182565720 creator A5059647775 @default.
• W2182565720 creator A5060313188 @default.
• W2182565720 creator A5066527655 @default.
• W2182565720 creator A5067575111 @default.
• W2182565720 creator A5075376934 @default.
• W2182565720 creator A5077088140 @default.
• W2182565720 creator A5088356514 @default.
• W2182565720 creator A5089965088 @default.
• W2182565720 creator A5089973047 @default.
• W2182565720 date "2007-04-18" @default.
• W2182565720 modified "2023-10-17" @default.
• W2182565720 title "Anticancer effect of a new benzophenanthridine isolated from Zanthoxylum madagascariense (Rutaceline)." @default.
• W2182565720 cites W1919851123 @default.
• W2182565720 cites W1978053614 @default.
• W2182565720 cites W1978819577 @default.
• W2182565720 cites W1990202861 @default.
• W2182565720 cites W1996989163 @default.
• W2182565720 cites W1998792806 @default.
• W2182565720 cites W1999260944 @default.
• W2182565720 cites W2018480686 @default.
• W2182565720 cites W2034485370 @default.
• W2182565720 cites W2042720290 @default.
• W2182565720 cites W2073100017 @default.
• W2182565720 cites W2085547973 @default.
• W2182565720 cites W2127345760 @default.
• W2182565720 cites W2135328894 @default.
• W2182565720 cites W2150335714 @default.
• W2182565720 cites W2166620479 @default.
• W2182565720 cites W2171691536 @default.
• W2182565720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17436597" @default.
• W2182565720 hasPublicationYear "2007" @default.
• W2182565720 type Work @default.
• W2182565720 sameAs 2182565720 @default.
• W2182565720 citedByCount "6" @default.
• W2182565720 countsByYear W21825657202015 @default.
• W2182565720 countsByYear W21825657202017 @default.
• W2182565720 countsByYear W21825657202018 @default.
• W2182565720 countsByYear W21825657202020 @default.
• W2182565720 crossrefType "journal-article" @default.
• W2182565720 hasAuthorship W2182565720A5023939276 @default.
• W2182565720 hasAuthorship W2182565720A5027349537 @default.
• W2182565720 hasAuthorship W2182565720A5041989247 @default.
• W2182565720 hasAuthorship W2182565720A5059647775 @default.
• W2182565720 hasAuthorship W2182565720A5060313188 @default.
• W2182565720 hasAuthorship W2182565720A5066527655 @default.
• W2182565720 hasAuthorship W2182565720A5067575111 @default.
• W2182565720 hasAuthorship W2182565720A5075376934 @default.
• W2182565720 hasAuthorship W2182565720A5077088140 @default.
• W2182565720 hasAuthorship W2182565720A5088356514 @default.
• W2182565720 hasAuthorship W2182565720A5089965088 @default.
• W2182565720 hasAuthorship W2182565720A5089973047 @default.
• W2182565720 hasConcept C143425029 @default.
• W2182565720 hasConcept C153911025 @default.
• W2182565720 hasConcept C185592680 @default.
• W2182565720 hasConcept C190283241 @default.
• W2182565720 hasConcept C202751555 @default.
• W2182565720 hasConcept C2777752497 @default.
• W2182565720 hasConcept C2777755551 @default.
• W2182565720 hasConcept C2778271344 @default.
• W2182565720 hasConcept C2779707156 @default.
• W2182565720 hasConcept C2780358455 @default.
• W2182565720 hasConcept C29537977 @default.
• W2182565720 hasConcept C54355233 @default.
• W2182565720 hasConcept C552990157 @default.
• W2182565720 hasConcept C55493867 @default.
• W2182565720 hasConcept C81885089 @default.
• W2182565720 hasConcept C86803240 @default.
• W2182565720 hasConcept C89138240 @default.
• W2182565720 hasConceptScore W2182565720C143425029 @default.
• W2182565720 hasConceptScore W2182565720C153911025 @default.
• W2182565720 hasConceptScore W2182565720C185592680 @default.
• W2182565720 hasConceptScore W2182565720C190283241 @default.
• W2182565720 hasConceptScore W2182565720C202751555 @default.
• W2182565720 hasConceptScore W2182565720C2777752497 @default.
• W2182565720 hasConceptScore W2182565720C2777755551 @default.
• W2182565720 hasConceptScore W2182565720C2778271344 @default.
• W2182565720 hasConceptScore W2182565720C2779707156 @default.
• W2182565720 hasConceptScore W2182565720C2780358455 @default.
• W2182565720 hasConceptScore W2182565720C29537977 @default.
• W2182565720 hasConceptScore W2182565720C54355233 @default.
• W2182565720 hasConceptScore W2182565720C552990157 @default.
• W2182565720 hasConceptScore W2182565720C55493867 @default.
• W2182565720 hasConceptScore W2182565720C81885089 @default.
• W2182565720 hasConceptScore W2182565720C86803240 @default.
• W2182565720 hasConceptScore W2182565720C89138240 @default.
• W2182565720 hasIssue "2" @default.
• W2182565720 hasLocation W21825657201 @default.
• W2182565720 hasOpenAccess W2182565720 @default.
• W2182565720 hasPrimaryLocation W21825657201 @default.
• W2182565720 hasRelatedWork W1661727823 @default.
• W2182565720 hasRelatedWork W2013674704 @default.
• W2182565720 hasRelatedWork W2352505828 @default.
• W2182565720 hasRelatedWork W2357393699 @default.

• next