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- W2182566923 abstract "The purpose of this work was to develop a rapid, sensitive and validated HPLC method for analysis of preservative agents “Methylparaben & Propylparaben” in topical creams containing steroids. The analysis were carried out on a reversed-phase C18 column (250 x 4.6 mm), with a mobile phase containing acetonitrile and water (65:35,v/v) at a flow rate of 1.5mL/min. The samples were detected using a UV detector at 240 nm. The method was validated according to USP 30 guideline recommendations and to the ICH guidelines for validation. The linearity, selectivity, accuracy, and robustness of the developed method showed acceptable values. The method is suitable for practical routine analysis of commercially produced topical creams containing steroids preparations and it was applied to analyze 47 samples of topical creams Produced in Syria containing steroids in the patient’s terms of use. All the analysis results were acceptable according to the pharmaceutical cream requirements." @default.
- W2182566923 created "2016-06-24" @default.
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- W2182566923 date "2013-01-01" @default.
- W2182566923 modified "2023-09-26" @default.
- W2182566923 title "Development of A Validated HPLC Method for the Analysis of Two Preservative Agents Methylparaben & Propylparaben in Topical Creams Containing Steroids in the Patient's Terms of Use" @default.
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