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• W2182573485 abstract "Both obesity prevalence and cardiovascular risk profile increases with age and it has been proven that this increase in visceral adipose tissue mass represents one of the most important factors associated with the development of an atherogenic metabolic profile for type 2 diabetes patients. Our study aimed to evaluate several clinical, biochemical and antropometric parameters together with their correlation with insulin secreting function of β-pancreatic cells and adipocytes function in obese newly diagnosed type 2 diabetes (ND-T2D). The study included 120 ND-T2D (74 men and 46 women) and 34 healthy subjects. The ND-T2D group were classified according to their body mass index (BMI) into two subgroups: overweight (25≤BMI<29.9 kg/m) and obese (BMI≥30 kg/m). All participants underwent antropometrical evaluation and routine blood parameters. Serum insulin, proinsulin, C peptide, leptin and adiponectin levels were also measured by ELISA method. We have found highly statistically significant differences between the control group and the other two subgroups of diabetic patients (overweight and obese), who have recorded values of double or more compared to the control group regarding clinical and biochemical measurements. Moreover, differences of 10-20% have also been observed between the overweight diabetic group and the obese diabetic group for proinsulin, C peptid and adiponectin (p<0.05). Serum insulin level was positive associated with weight, creatinine and waist circumferance (WC) while serum proinsulin was positively correlated only with WC (p<0.005). Leptin was positively associated with BMI (p<0.05) while adiponectin was negatively correlated with BMI (p<0.001). High proinsulin levels, confirm an overload of the β-pancreatic cells in overweight/obese subjects while decreased adiponectin levels in obese ND-T2D make excess weight an essential risk factor for diabetes even before the decompensation of blood glucose regulation." @default.
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• W2182573485 date "2014-01-01" @default.
• W2182573485 modified "2023-10-15" @default.
• W2182573485 title "CORRELATIONS BETWEEN ADIPOCYTOKINES AND ANTROPOMETRIC MARKERS IN NEWLY DIAGNOSED OBESE TYPE 2 DIABETES MELLITUS" @default.
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