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• W2182594872 abstract "Motivation: A new protocol for sequencing the messenger RNA in a cell, known as RNA-Seq, generates millions of short sequence fragments in a single run. These fragments, or ‘reads’, can be used to measure levels of gene expression and to identify novel splice variants of genes. However, current software for aligning RNA-Seq data to a genome relies on known splice junctions and cannot identify novel ones. TopHat is an efficient read-mapping algorithm designed to align reads from an RNA-Seq experiment to a reference genome without relying on known splice sites. Results: We mapped the RNA-Seq reads from a recent mammalian RNA-Seq experiment and recovered more than 72% of the splice junctions reported by the annotation-based software from that study, along with nearly 20 000 previously unreported junctions. The TopHat pipeline is much faster than previous systems, mapping nearly 2.2 million reads per CPU hour, which is sufficient to process an entire RNA-Seq experiment in less than a day on a standard desktop computer. We describe several challenges unique to ab initio splice site discovery from RNA-Seq reads that will require further algorithm development." @default.
• W2182594872 created "2016-06-24" @default.
• W2182594872 creator A5016854384 @default.
• W2182594872 creator A5044103741 @default.
• W2182594872 creator A5077359086 @default.
• W2182594872 date "2009-01-01" @default.
• W2182594872 modified "2023-09-26" @default.
• W2182594872 title "BIOINFORMATICS ORIGINAL PAPER" @default.
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