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- W2182690686 abstract "Cissus corniifolia commonly called splanch, has bee n allegedly used in the treatment of diabetes. The effect of methanolic leaf extract of this plant on glucose co ncentration and histopathology of the pancreas and liver were assessed. The preliminary phytochemical screening omethanolic extract of Cissus cornifolia revealed the presences of alkaloid, flavonoid, saponin, steroid, terpenoid and tannin. Also, the LD 50 of the extract was found to be above 5000mg/kg orally. Rats were made diabetic by intraperitoneal injection of 150mg/kg body weigh t of Alloxan monohydride and divided into five (5 ) 1-5 with group 5 rats in each group. Groups 2-4 were treated with 50,100 and 200mg/kg body weight of the extract resp ectively while group 1 and 5 was served as negative and positive controls respectively. The fasting blood glucose levels were determined at intervals of 0, 1 , 3, 5, 7, 9, 11 and 13 days. On day 0 there were no significant dif ferences in the fasting blood glucose levels in all the groups when compared with the control. As regard to the do se of 100 mg/kg 7 days extract administration there was a significant decrease in the blood glucose levels wh en compared with control group. Glibenclamide as a positive control significantly reduce the fasting blood gluc ose level at 11 and 13 days respectively when compa red to the negative control .The highest activity reside at th e lowest dose of the extract administered 50mg/kg b ody weight. At the end of two weeks of the experiment, the animals were sacrificed and the pancreas and liver were se ction for histopathology. The histopathological studies of th e pancreas of diabetic animals revealed the degener ation of pancreatic islet cells, but with the restoration after treatment with various doses of the plant extra ct. The liver shows no histopathological change. The implications of th e result obtained in the present study provide the scientific rationale for the use of Cissus cornifolia as anti- diabetic agent in the management of diabetes." @default.
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- W2182690686 date "2013-01-01" @default.
- W2182690686 modified "2023-09-24" @default.
- W2182690686 title "Anti-diabetic effect of methanolic leaf extract of Cissus cornifolia on alloxan-induced hyperglycemic in wistar rats" @default.
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