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- W2182721190 abstract "during the 2 nd 5-min session was an indicator of antidepressant activity. Salvinorin A showed a dose-dependent increase in the mean number of entries and time spent in the open arms and a decrease of the mean time spent in immobility. Pre-treatment with the k opioid antagonist, norbinaltorphimine (10 mg/kg i.p.), and with the CB1 cannabinoid receptor antagonist AM 251 (3 mg/kg i.p.), given 2 h and 40 min before salvinorin A respectively, significantly blocked the anxiolytic and antidepressant effect. These findings support for the first time the demonstration of the emotional response induced by salvinorin A through a mechanism cannabinoid CB1 receptor mediated." @default.
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- W2182721190 date "2007-06-01" @default.
- W2182721190 modified "2023-09-27" @default.
- W2182721190 title "Involvement of the cannabinoid receptor type-1 (CB1) on Salvinorin-A-induced emotional response in rats" @default.
- W2182721190 hasPublicationYear "2007" @default.
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