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- W2182729683 abstract "Acute leucine intoxication and neurologic deterioration can develop rapidly at any age as a result of net protein degradation precipitated by infection or psychological stress in patients with maple syrup urine disease (MSUD). Here, we investigated the effects of acute and chronic Hyper-BCAA (H-BCAA) administration on pro- and anti-inflammatory cytokines in the brains of rats. For acute administration, Wistar rats (10 and 30 days) received three injections of BCAA pool (15.8 μL/g at 1-h intervals) or saline, subcutaneously. For chronic administration, Wistar rats (7 days) received of BCAA pool or saline twice a day for 21 days, subcutaneously. Our results showed that acute administration of H-BCAA increased IL-1β (∼ 78%; p ≤ 0.009) and TNF-α (∼ 155%; p ≤ 0.026) levels in the cerebral cortex but not in the hippocampus of infant rats. Moreover, IL-6 levels were increased in the hippocampus (∼ 135%; p ≤ 0.009) and cerebral cortex (∼ 417%; p ≤ 0.008), whereas IL-10 levels were decreased only in the hippocampus (∼ 42%; p ≤ 0.009). However, repeated administration of H-BCAA decreased IL-1β (∼ 59%; p ≤ 0.047), IL-6 (∼ 70%; p ≤ 0.009) and IFN-γ (∼ 70%; p ≤ 0.008) levels in the cerebral cortex, whereas the IL-6 (∼ 67%; p ≤ 0.009), IL-10 (∼ 58%; p ≤ 0.01) and IFN-γ (∼ 67%; p ≤ 0.009) levels were decreased in the hippocampus. These findings suggest that a better understanding of the inflammatory response in MSUD patients may be useful to develop therapeutic strategies to modulate the hyperinflammatory/hypoinflammatory axis." @default.
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- W2182729683 date "2015-11-30" @default.
- W2182729683 modified "2023-09-25" @default.
- W2182729683 title "Administration of branched‐chain amino acids alters the balance between pro‐inflammatory and anti‐inflammatory cytokines" @default.
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- W2182729683 cites W1969553044 @default.
- W2182729683 cites W1971673889 @default.
- W2182729683 cites W1978072893 @default.
- W2182729683 cites W1978233646 @default.
- W2182729683 cites W1979369962 @default.
- W2182729683 cites W1981678409 @default.
- W2182729683 cites W1985538633 @default.
- W2182729683 cites W1986546465 @default.
- W2182729683 cites W1993469517 @default.
- W2182729683 cites W2000852460 @default.
- W2182729683 cites W2001977126 @default.
- W2182729683 cites W2003123811 @default.
- W2182729683 cites W2003860356 @default.
- W2182729683 cites W2004297047 @default.
- W2182729683 cites W2005888979 @default.
- W2182729683 cites W2008657946 @default.
- W2182729683 cites W2011531635 @default.
- W2182729683 cites W2015851283 @default.
- W2182729683 cites W2015986778 @default.
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- W2182729683 cites W2034657358 @default.
- W2182729683 cites W2040160616 @default.
- W2182729683 cites W2041112741 @default.
- W2182729683 cites W2043490836 @default.
- W2182729683 cites W2047512700 @default.
- W2182729683 cites W2050490622 @default.
- W2182729683 cites W2054529675 @default.
- W2182729683 cites W2054998165 @default.
- W2182729683 cites W2058890595 @default.
- W2182729683 cites W2061411308 @default.
- W2182729683 cites W2066613757 @default.
- W2182729683 cites W2066736421 @default.
- W2182729683 cites W2069755236 @default.
- W2182729683 cites W2070228148 @default.
- W2182729683 cites W2078352891 @default.
- W2182729683 cites W2081074905 @default.
- W2182729683 cites W2081620856 @default.
- W2182729683 cites W2082747881 @default.
- W2182729683 cites W2084891703 @default.
- W2182729683 cites W2086215295 @default.
- W2182729683 cites W2087079891 @default.
- W2182729683 cites W2088983976 @default.
- W2182729683 cites W2097867538 @default.
- W2182729683 cites W2105114664 @default.
- W2182729683 cites W2105287799 @default.
- W2182729683 cites W2105896882 @default.
- W2182729683 cites W2106198861 @default.
- W2182729683 cites W2107997122 @default.
- W2182729683 cites W2108216811 @default.
- W2182729683 cites W2113010696 @default.
- W2182729683 cites W2119203984 @default.
- W2182729683 cites W2133036882 @default.
- W2182729683 cites W2134960956 @default.
- W2182729683 cites W2148115594 @default.
- W2182729683 cites W2151539516 @default.
- W2182729683 cites W2160700926 @default.
- W2182729683 cites W2168190675 @default.
- W2182729683 cites W2168533782 @default.
- W2182729683 cites W2168561180 @default.
- W2182729683 cites W2291383555 @default.
- W2182729683 cites W2330770873 @default.
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- W2182729683 doi "https://doi.org/10.1016/j.ijdevneu.2015.11.002" @default.
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- W2182729683 hasPublicationYear "2015" @default.
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