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- W2182731941 endingPage "828" @default.
- W2182731941 startingPage "813" @default.
- W2182731941 abstract "Bisulfite treatment-based methylation microarray (mainly Illumina 450K Infinium array) and next-generation sequencing (reduced representation bisulfite sequencing, Agilent SureSelect Human Methyl-Seq, NimbleGen SeqCap Epi CpGiant or whole-genome bisulfite sequencing) are commonly used for base resolution DNA methylome research. Although multiple tools and methods have been developed and used for the data preprocessing and analysis, confusions remains for these platforms including how and whether the 450k array should be normalized; which platform should be used to better fit researchers' needs; and which statistical models would be more appropriate for differential methylation analysis. This review presents the commonly used platforms and compares the pros and cons of each in methylome profiling. We then discuss approaches to study design, data normalization, bias correction and model selection for differentially methylated individual CpGs and regions." @default.
- W2182731941 created "2016-06-24" @default.
- W2182731941 creator A5004014661 @default.
- W2182731941 creator A5004264491 @default.
- W2182731941 creator A5067100969 @default.
- W2182731941 creator A5067865294 @default.
- W2182731941 date "2015-08-01" @default.
- W2182731941 modified "2023-10-18" @default.
- W2182731941 title "Base resolution methylome profiling: considerations in platform selection, data preprocessing and analysis" @default.
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- W2182731941 doi "https://doi.org/10.2217/epi.15.21" @default.
- W2182731941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4790440" @default.
- W2182731941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26366945" @default.
- W2182731941 hasPublicationYear "2015" @default.
- W2182731941 type Work @default.