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- W2182746672 abstract "The spermatozoon and oocyte genomes bear sex-specific methylation patterns that are established during gametogenesis and are required for the allele-specific expression of imprinted genes in somatic tissues. The mRNA for Dnmt1, the predominant maintenance and de novo DNA (cytosine-5)-methyl transferase in mammals, is present at high levels in postmitotic murine germ cells but undergoes alternative splicing of sex-specific 5′ exons, which controls the production and localization of enzyme during specific stages of gametogenesis. An oocyte-specific 5′ exon is associated with the production of very large amounts of active Dnmt1 protein, which is truncated at the N terminus and sequestered in the cytoplasm during the later stages of oocyte growth, while a spermatocyte-specific 5′ exon interferes with translation and prevents production of Dnmt1 during the prolonged crossing-over stage of male meiosis. During the course of postnatal oogenesis, Dnmt1 is present at high levels in nuclei only in growing dictyate oocytes, a stage during which gynogenetic developmental potential is lost and biparental developmental potential is gained." @default.
- W2182746672 created "2016-06-24" @default.
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- W2182746672 date "1998-03-01" @default.
- W2182746672 modified "2023-10-17" @default.
- W2182746672 title "Sex-specific exons control DNA methyltransferase in mammalian germ cells" @default.
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- W2182746672 doi "https://doi.org/10.1242/dev.125.5.889" @default.
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