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- W2182747926 abstract "The spinal cord is a predominant site of lesions in multiple sclerosis (MS) and its variants, particularly in Asian populations. We investigated postmortem spinal cords obtained from 4 patients with acute MS, 9 patients with chronic MS and 4 controls. A total of 387 spinal cord segments were examined to study the histopathology of myelin, axons, glia, and immune reactions with routine histopathological stains and immunohistochemistry. The cross-sectional areas of the spinal cord and demyelinating plaques were measured and correlations with disease duration were sought. We found a high incidence of spinal cord lesions with highly heterogeneous pathology, including diverse demyelinating plaques and necrosis in acute patients, and Wallerian degeneration in chronic patients. The cervical and upper thoracic cords most frequently had demyelinating plaques in the lateral and dorsal columns and in the dorsal horn with various topographic patterns. In acute patients, coagulation necrosis and edema with various topographic patterns. In acute patients, coagulation necrosis and edema . In acute patients, coagulation necrosis and edema In acute patients, coagulation necrosis and edema oagulation necrosis and edema and edema" @default.
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- W2182747926 date "2006-01-01" @default.
- W2182747926 modified "2023-09-26" @default.
- W2182747926 title "Heterogeneity of spinal cord pathology in multiple sclerosis and variants: A study of postmortem specimen from 13 Asian patients" @default.
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