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• W2182784656 abstract "Hesperidin (HSP) is a natural plant extract which has various effective biological activities. HSP showed promising schistosomicidal properties against adult worms of Schistosoma mansoni (S. mansoni) both in vivo and in vitro. The aim of the present study was to evaluate the in vivo schistosomicidal effects of HSP on juvenile and adult stages of S. mansoni concerning parasitological, pathological and immunological parameters in murine model of infection. Swiss albino mice were used to achieve this aim. They were classified into 7 groups (10 mice in each group): group I which included normal control mice, group II which included infected untreated control mice (IU), group III given early HSP treatment, beginning on the first day of infection, group IV given early HSP+PZQ, group V given late HSP treatment, starting at the 4 th week post-infection, group VI given late HSP+PZQ and group VII given PZQ alone. The highest reduction percentages of worm burden and tissue egg load were recorded in groups IV, VI and VII. The same groups showed the highest significant decrease in percentage of immature and mature ova and the highest significant increase in percentage of dead ova. Early HSP treatment gave the highest significant reduction in both granuloma number and diameter. There was significant increase in IgG level in response to S. mansoni soluble worm antigen protein in all treated mice groups. Also, early HSP treatment revealed the highest decrease in serum levels of IL-6, IL-12 and TNF-α and the highest increase in serum level of IL-10, while both early HSP and early HSP+PZQ treatments showed the highest decrease in serum level of IFN-γ. In conclusion, HSP treatment achieved promising schistosomicidal activities, especially when given early after exposure to S. mansoni infection, in addition it alleviated hepatic pathology by affecting some cytokines that are involved in granuloma formation. (Bahaa El Deen W. El Aswad and Gehan S. Sadek. Parasitological, pathological and immunological effects of hesperidin treatment on murine schistosomiasis mansoni. Life Sci J 2014;11(7):840-855) (ISSN:1097- 8135). http://www.lifesciencesite.com. 121" @default.
• W2182784656 created "2016-06-24" @default.
• W2182784656 creator A5060755408 @default.
• W2182784656 creator A5077043121 @default.
• W2182784656 creator A5084565923 @default.
• W2182784656 date "2014-01-01" @default.
• W2182784656 modified "2023-09-27" @default.
• W2182784656 title "Parasitological, pathological and immunological effects of hesperidin treatment on murine schistosomiasis mansoni" @default.
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