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- W2182790542 abstract "In a previous study we found that plasma levels of retinol and tocopherol tend to decrease for increasing degrees of liver cirrhosis (LC) (J Lab Clin Med 1991;118: 176). Aiming to verify whether retinol and tocopherol could be employed as markers of LC severity, we measured them in 141 consecutive cirrhotics and 48 healthy controls. Statistically significant differences in plasma retinol levels were found between controls (2.37 ± 0.94 μmol/l), Child-Pugh (CP) A (1.50 ± 0.90 μmol/l, n = 60), CPB (0.84 ± 0.42 μmol/l, n = 51) and CPC patients (0.56 ± 0.38 μmol/l, n = 30; p < 0.01 for CPA vs CPB, CPA vs CPC, CPA vs controls, CPB vs controls, CPC vs controls and p < 0.05 for CPB vs CPC). Patients with hepatocarcinoma (HCC) superimposed on LC showed lower levels of retinol as compared to those without HCC (0.38 ± 0.07, n = 34 vs 0.83 ± 0.08 μmol/l, n = 107, p < 0.05). While a decreasing trend was observed also for tocopherol, between-group differences were not always significant. Moreover, tocopherol levels were similar in cirrhotics with and without HCC. Age, sex and body mass index did not influence the relationship between retinol or tocopherol levels and LC degree (p = ns, ANCOVA). Our study suggests that retinol has the potential to be employed as an index of disease severity in LC patients." @default.
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- W2182790542 date "1999-01-01" @default.
- W2182790542 modified "2023-09-24" @default.
- W2182790542 title "Relationship between plasma levels of retinol and tocopherol and disease severity in patients with liver cirrhosis" @default.
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