Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182796934> ?p ?o ?g. }
- W2182796934 abstract "Brown adipose tissue (BAT) is considered an interesting target organ for the treatment of metabolic disease due to its high metabolic capacity. Non-shivering thermogenesis, once activated, can lead to enhanced partitioning and oxidation of fuels in adipose tissues, and reduce the burden of glucose and lipids on other metabolic organs such as liver, pancreas and skeletal muscle. Sustained long-term activation of BAT may also lead to meaningful bodyweight loss. In this review, we discuss three different drug classes (the thiazolidinedione (TZD) class of PPAR agonists, 3 adrenergic receptor agonists and fibroblast growth factor 21 (FGF21) analogues) that have been proposed to regulate BAT and beige recruitment or activation, or both, and which have been tested in both rodent and human. The learnings from these classes suggest that restoration of functional BAT and beige mass as well as improved activation might be required to fully realize the metabolic potential of these tissues. Whether this can be achieved without the undesired cardiovascular side-effects exhibited by the TZD PPAR agonists and 3 adrenergic receptor agonists remains to be resolved." @default.
- W2182796934 created "2016-06-24" @default.
- W2182796934 creator A5002506738 @default.
- W2182796934 creator A5011756139 @default.
- W2182796934 creator A5034330153 @default.
- W2182796934 creator A5070282117 @default.
- W2182796934 date "2015-11-19" @default.
- W2182796934 modified "2023-09-25" @default.
- W2182796934 title "Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity" @default.
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