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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182824055> ?p ?o ?g. }

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• W2182824055 abstract "Herpes simplex virus immediate-early (IE) promoters contain the TAATGARAT motif which acts as a target site for the cellular POU family transcription factors Oct-1 and Oct-2. Here we show that other members of the POU family that are expressed in sensory neurons can also affect IE promoter activity. In particular, two members of the Brn-3 family of POU proteins Brn-3a and Brn-3c can activate the IE-1 and IE-3 promoters when co-transfected into fibroblasts and neuronal cells whereas a third member Brn-3b represses IE promoter activity. In contrast, Brn-3 proteins cannot overcome the inhibitory effect of neuronal Oct-2 on IE promoter activity in co-transfections nor do they prevent transactivation of the IE promoters by the Oct-1-Vmw65 complex. The potential regulation of the IE promoters by several different neuronally expressed POU proteins during the initiation, maintenance and re-activation of latent infection in sensory neurons is discussed." @default.
• W2182824055 created "2016-06-24" @default.
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• W2182824055 date "1995-04-15" @default.
• W2182824055 modified "2023-09-27" @default.
• W2182824055 title "Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors" @default.
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• W2182824055 doi "https://doi.org/10.1042/bj3070581" @default.
• W2182824055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1136687" @default.
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